Patents by Inventor Roger A. Bakale

Roger A. Bakale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating and preventing a convulsive state
    Patent number: 6946464
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (?)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (?)-N-desmethylzopiclone.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: September 20, 2005
    Assignee: Sepracor Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Method of resolving amlodipine racemate
    Publication number: 20050009887
    Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N?-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.
    Type: Application
    Filed: August 4, 2004
    Publication date: January 13, 2005
    Applicant: Sepracor Inc.
    Inventors: Chris Senanayake, Gerald Tanoury, Harold Wilkinson, Roger Bakale, Andrei Zlota, Kostas Saranteas
  • Levalbuterol salt
    Publication number: 20040115136
    Abstract: Levalbuterol L-tartrate affords crystals possessing properties desirable for use in a metered dose inhaler.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 17, 2004
    Inventors: Paul McGlynn, Roger Bakale, Craig Sturge
  • Methods of making and using N-desmethylzopiclone
    Publication number: 20030166657
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Application
    Filed: January 13, 2003
    Publication date: September 4, 2003
    Applicant: Sepracor, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Methods of making N-desmethylzopiclone
    Publication number: 20030119841
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Application
    Filed: September 30, 2002
    Publication date: June 26, 2003
    Applicant: Sepracor, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Methods of making and using N-desmethylzopiclone
    Patent number: 6506753
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: January 14, 2003
    Assignee: Sepracor, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Methods of treating muscle spasms using N-desmethylzopiclone
    Publication number: 20020143016
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Application
    Filed: January 9, 2002
    Publication date: October 3, 2002
    Applicant: Sepracor, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Methods of treating muscle spasms using N-desmethylzopiclone
    Patent number: 6458791
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: October 1, 2002
    Assignee: Sepracor, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville
  • Methods of making and using N-desmethylzopiclone
    Publication number: 20020019398
    Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (+)-N-desmethylzopiclone, and optically pure (−)-N-desmethylzopiclone.
    Type: Application
    Filed: June 11, 2001
    Publication date: February 14, 2002
    Applicant: SEPRACOR, Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Paul D. Rubin, Yaping Hong, Roger A. Bakale, Tingjian Xiang, Fran A. McConville