Abstract: The present invention provides a recombinant polypeptide comprising a first portion and a second portion, wherein the sequence of the first portion is fully identical to amino acids 1 to 248 of the sequence set forth as SEQ ID NO:1 and the sequence of the second portion is other than amino acids 249 to 511 of the sequence set forth as SEQ ID NO:1.

Abstract: The present invention relates to 9-substituted adenine derivatives represented by formula (I) wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected from the group consisting of O, S, N(H), CH2, CH and C; Y is selected from the group consisting of H, hydroxy, C1-4 alkyl, C1-4 alkoxy and halogen; R is selected from the group consisting of H, hydroxymethyl, C1-4 alkyl, and C1-4 alkoxy; R1is selected from the group consisting of O, NH and CH2; R2represents a radical selected from the group consisting of —(CH2)n—S—C(O)—R4 and —(CH2)n—S—S—R4, where n=1-4 and R4is a C1-4-alkyl or aryl group and R4 is optionally substituted with a halogen, amino, N-alkylamino, N, N-dialkylamino or C1-4 alkoxy group and wherein each of the R2radicals may be the same or different; and R3is O or S. The derivatives are useful as prodrugs for inhibiting adenylyl cyclase and lowering 3?:5?-cAMP in cells, thereby inhibiting adenylyl cyclase dependent effects within cells.

Abstract: A method of manufacturing a composite uses a hybrid tool which serves both as a form on which constituent materials are applied for bonding or curing into a part in a desired configuration, and as a fixture for holding the bonded or cured materials in the originally applied position during subsequent machining of a peripheral edge of the part. The method includes fabricating a face sheet of composite material having a facing surface configured to the reverse of a desired shape of one surface of a part to be made on the tool. The materials for the part are applied on the face sheet, debulked, bonded or cured, and edge trimmed thereon, all while on the face sheet in the originally applied position.

Abstract: The present invention relates to 9-substituted adenine derivatives that inhibit adenylyl cyclase in cells but have little or no effect on isolated adenylyl cyclase. The derivatives are useful as prodrugs for inhibiting adenylyl cyclase and lowering 3′:5′-cAMP in cells, thereby inhibiting adenylyl cyclase dependent effects within cells.

Abstract: An assembly tool for setting a lateral position of a rear window panel placed on a window glass support surface of a rear window opening of an automotive vehicle is provided. The tool includes an upper jaw for extending over a C pillar of the automotive vehicle, the upper jaw has a weather strip channel contact member and an adjustable length extending finger with an extreme edge window contacting surface for setting a lateral position of the rear window panel within the window glass support surfaces. A lower jaw pivotally is connected with the upper jaw for contacting and gripping an inboard surface of the vehicle C pillar. A quick connect vice mechanism for closing the upper jaw and the lower jaw toward one another to grip the C pillar is also included.

Abstract: A hybrid tool serves as a form on which constituent materials are applied for bonding or curing into a part in a desired configuration. It also serves as a holder for the bonded or cured materials in the originally applied position during subsequent machining. The hybrid tool is made by fabricating a face sheet of composite material having a facing surface configured to the reverse of a desired shape of one surface of a part to be made on the tool. The actual part will be laid up on the facing surface, cured while on the tool, and even trimmed before release. Base structure of the tool holds the facing surface of the face sheet in the desired shape, and includes ground-engaging pads that define an “A” datum plane. The tool aligns a reference plane of the face sheet parallel to the datum plane. A substantially continuous groove in the face sheet, used for trimming the part, opens in the facing surface.

Abstract: The present invention reveals a new series of derivatives and analogues of adenine and adenosine, i.e., 3'-adenosine derivatives, which inhibit adenylyl cyclase activity. These newly synthesized compounds include the most potent inhibitors of adenylyl cyclases known. The present invention also discloses a method for measuring the inhibition of adenylyl cyclase activity.

Abstract: A hybrid tool serves as a form on which constituent materials are applied for bonding or curing into a part in a desired configuration. It also serves as a holder for the bonded or cured materials in the originally applied position during subsequent machining. The hybrid tool is made by fabricating a face sheet of composite material having a facing surface configured to the reverse of a desired shape of one surface of a part to be made on the tool. The actual part will be laid up on the facing surface, cured while on the tool, and even trimmed before release. Base structure of the tool holds the facing surface of the face sheet in the desired shape, and includes ground-engaging pads that define an "A" datum plane. The tool aligns a reference plane of the face sheet parallel to the datum plane. A substantially continuous groove in the face sheet, used for trimming the part, opens in the facing surface.

Abstract: The present invention reveals a new series of derivatives and analogues of adenine and adenosine, i.e., 3'-adenosine derivatives, which inhibit adenylyl cyclase activity. These newly synthesized compounds include the most potent inhibitors of adenylyl cyclases known. The present invention also discloses a method for measuring the inhibition of adenylyl cyclase activity.

Abstract: At predetermined low speeds, a safety brake is applied directly to the hoisting drum at a setting sufficiently high to stop the load from falling should drive line failure occur. The load can be lowered or raised by applying sufficient torque to the drum to overcome the braking force and thus lower or raise the load. If drive train failure occurs, the brake will instantaneously stop the load without further uncontrolled movement.

Abstract: A shut-off valve for a spin-on filter includes a generally cylindrical outer housing which has an open top surface and an annular spring channel formed in that top surface for receipt of a coil spring. The spring is positioned so as to act on a valve actuator and gasket combination which are moveable relative to a valve seat for opening and closing the shut-off valve. In the normally closed condition the spring exerts a spring biasing force on the upper portion of the valve actuator which pushes it against the gasket and pushes the gasket against the outer sealing ridge of the valve seat. In this condition any liquid flowing into the top center opening of the housing will not be allowed to pass through the lowered centered opening of the valve seat. However, when the spin-on filter which includes the shut-off valve is spun onto a mounting base a stem on that mounting base pushes upwardly on the valve actuator compressing the spring and creating a liquid flow path between the gasket and the valve seat.

Abstract: A double-enveloped lamp assembly includes a light-source capsule subject to burst on rare occasions, a light-transmissive shield substantially surrounding the light-source capsule for absorbing and dissipating a portion of the energy when the light-source capsule bursts, a mesh of substantially nonconducting fiber for reinforcing the shield, and a light-transmissive outer envelope. The mesh is fabricated of ceramic fibers having sufficient strength to reinforce the shield. Since the fibers are nonconducting, sodium migration is minimized. The ceramic fiber mesh is particularly useful for high wattage lamps where thick-walled outer envelopes are not practical.

Abstract: A ceramic arc tube assembly for an arc discharge lamp includes an arc tube having openings for electrode feedthroughs at opposite ends. The feedthroughs each comprise a niobium tube having a tungsten electrode welded to it. A connection wire is welded to the feedthrough at or near the end of the niobium tube, and the feedthrough is subsequently sealed into the arc tube with the connection wire abutting the arc tube. Since the connection wire is prewelded to the feedthrough, the feedthrough can be made as short as practicable without risk of damaging the seal during welding. As a result, feedthrough material cost is substantially reduced. Preferably, the connection wire is used for locating the feedthrough in the arc tube during seal formation.

Abstract: A patient transport device which is characterized in one embodiment by a flat rail bed having spaced, parallel, upturned rails on opposite sides, with a seat slidably disposed over the rails by means of rollers rotating in the rails on spaced axles carried by the seat. The device is designed to transport patients from one side of a bed to the other, as well as to and from wheelchairs and dollys. In another embodiment, the seat is enlarged to define a body support, the body support and rail bed combination is supported by hydraulic cylinders to facilitate height adjustment and the larger patient transport device is used to transport patients to and from x-ray tables, dollys, hospital beds and the like.

Abstract: The safety system in a hoist having a motor with a motor shaft, a gear reduction unit, a drum, a safety brake drivingly coupled on an operating element on or close to the drum in which a mechanical out-of-sync detector produces a unidirectional brake-setting output from inputs from the drum and the motor shaft, the unidirectional brake-setting rotational output for setting the brake. In a preferred embodiment, an error correction is made into the detector for obtaining a first unidirectional output during normal operation, and the brake-setting unidirectional rotation is in the opposite direction for setting the brake. One form of detector is a mechanical differential assembly and another form of detector is a set of coaxial shafts that measure differential rotation between the drum and motor input shafts. A unique brake actuator is provided and is easily reset remotely after the brake has been set.

Abstract: ATP and other nucleoside triphosphates labeled in the .gamma.-phosphate with .sup.32 P are prepared from L-.alpha.-glycerophosphate and their corresponding nucleoside diphosphates by a series of enzymatic reactions in the presence of NAD.sup.+, preferably regenerated by lactate dehydrogenase and pyruvate. The resulting [.gamma.-.sup.32 P]nucleotides are useful as reagents for analytical determinations.

Abstract: In a process for preparing pigmentary .gamma.-quinacridone by oxidizing .beta.-dihydroquinacridone with a mild alkali-stable oxidizing agent in a liquid medium consisting of alkali metal hydroxide, water and a polar, alkali-stable, water-soluble organic liquid, this invention provides for an improvement wherein the oxidation is conducted in the presence of 0.1% to 1% by weight of an o-carboxybenzamidomethyl quinacridone compound whereby the resulting .gamma.-quinacridone exhibits sufficiently high strength so that milling or solvent treatments to increase pigment strength are unnecessary.