Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

Abstract: Aligning an optical fibre with an optical device, component or package such as an optical transducer or sensor is disclosed, A housing for an optical device is provided having a tapered surface to receive a correspondingly tapered portion of a ferrule in which a fibre is mounted. The tapered surfaces, which may for example be frusta-conical or conical, enable the optical device and ferrule to be quickly and precisely aligned. An optical device may be provided in a cavity which may be sealed by the mating tapered surfaces. The optical device may also be provided on a mounting bracket with flexible supports connected to the housing to accommodate thermal expansion of the housing and maintain alignment.

Abstract: A method and system for aligning a sensor of a radar unit mounted on a vehicle, including calculating at least one alignment measurement of the vehicle from a plurality of optical sensors, positioning a target at a predetermined distance forward of the radar unit and determining a position of the radar unit based on the alignment measurement and the predetermined distance of the target. The method further includes transmitting a beam extending forward from the radar unit and positioning the target and the sensor in alignment with an axis of the beam.

Abstract: The invention provides new biotinylated compounds and methods for their use.

Abstract: Provided herein are compounds of formula Ia: and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula Ia, processes for preparing compounds of formula Ia, intermediates useful for preparing compounds of formula Ia and therapeutic methods using compounds of formula Ia.

Abstract: A method and system for aligning a sensor of a radar unit mounted on a vehicle, including calculating at least one alignment measurement of the vehicle from a plurality of optical sensors, positioning a target at a predetermined distance forward of the radar unit and determining a position of the radar unit based on the alignment measurement and the predetermined distance of the target. The method further includes transmitting a beam extending forward from the radar unit and positioning the target and the sensor in alignment with an axis of the beam.

Abstract: The invention provides new biotinylated compounds and methods for their use.

Abstract: The invention provides analogs cyclic diguanosine monophosphate (c-di-GMP) having different substituents at the guanine C8 position.

Abstract: A method may include transmitting, during a point-to-point over Ethernet (PPPoE) discovery stage, a PPPoE active discovery (PAD) packet from a customer premises equipment (CPE) device to an access concentrator. The PAD packet may include a tag that is associated with a device type of the CPE device. The method may include receiving a PPPoE active discovery session (PADS) confirmation packet from the access concentrator. The PADS confirmation packet may be associated with conclusion of the PPPoE discovery stage and establishment of an Ethernet communication session between the CPE device and the access concentrator.

Abstract: The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates.

Abstract: Network services systems and methods are provided. A particular system includes an information store including connection information to initiate connections to content sources. The connection information includes an address and a connection rule associated with a video content source. The system includes an access engine to receive a request for an information stream output by the video content source from a user device. The system also includes a services engine to retrieve the connection rule from the information store and to initiate establishment of at least a portion of a point to point protocol communication link between the user device and the video content source in accordance with the connection rule. The system includes a metrics engine to track a metric associated with the point to point protocol communication link and to generate a billing record at least partially based upon the metric.

Abstract: A computer implemented method includes sending a request from a customer service terminal to a broadband remote access server to retrieve a device identifier of a customer premises equipment device. The device identifier is received by the broadband remote access server via a point to point protocol over ethernet active discovery initiation packet sent from the customer premises equipment device. The computer implemented method includes receiving, at the customer service terminal, a response from the broadband remote access server that includes the device identifier of the customer premises equipment device.

Abstract: The invention provides analogs cyclic diguanosine monophosphate (c-di-GMP) having different substituents at the guanine C8 position.

Abstract: Systems and methods for processing data and communicating encrypted data are provided. A method of processing data and communicating encrypted data may include receiving input traffic data at a first interface of a channel service unit/data service unit (CSU/DSU). The method may also include encrypting management data associated with the input traffic data at the CSU/DSU to produce encrypted management data. The method may further include sending the encrypted management data via a second interface of the CSU/DSU to a remote terminal of a local area network via a data router coupled to the CSU/DSU.

Abstract: A method may include transmitting, during a point-to-point over Ethernet (PPPoE) discovery stage, a PPPoE active discovery (PAD) packet from a customer premises equipment (CPE) device to an access concentrator. The PAD packet may include a tag that is associated with a device type of the CPE device. The method may include receiving a PPPoE active discovery session (PADS) confirmation packet from the access concentrator. The PADS confirmation packet may be associated with conclusion of the PPPoE discovery stage and establishment of an Ethernet communication session between the CPE device and the access concentrator.

Abstract: In a particular embodiment, the disclosure is directed to a method of making a digital subscriber line (DSL) connection to a remote network. The method includes detecting the presence of a powered-on network capable device that is connected to a DSL modem; establishing a network connection over a DSL line to the remote network after detecting the presence of the powered on network capable device; terminating the network connection over the DSL line after detecting an absence of network capable devices connected to the DSL modem; and releasing network resources supported by the remote network after the network connection is terminated.

Abstract: An adapter is provided for adapting an optical instrument, such as a camera (3) or a projector, to capture or display panoramic three-dimensional images. The adapter comprises a plurality of mirrors (1a, 1b, 1c), each of which has a reflective surface which is in the shape of a curved non-circular conic section rotated about an axis of symmetry (15a, 15b, 15c). The reflective surfaces have first foci which are spaced perpendicularly from a longitudinal axis of the adapter and which are angularly spaced around the longitudinal axis. For example, the conic section may be a hyperbola with first foci equidistantly spaced from the longitudinal axis and equiangularly spaced around 15b the longitudinal axis. The axes of symmetry (15a, 15b, 15c) of the mirrors (1a, 1b, 1c) converge to intersect the longitudinal axis at a point which is coincident with the front principal point of, for example, a camera lens (12).

Abstract: A display device is provided that comprises a liquid crystal display panel (2) for displaying an image by spatial light modulation. The image is represented by a plurality of image elements each having an image data value (7). The display device further comprises a display controller (1) arranged to determine a signal voltage to be applied to the panel (2) for each image element in dependence upon its image data value (7) and a secondary data value (8) for the element, there being a predetermined mapping between the data values and the signal voltage. The secondary data values (8) are arranged to vary across the image so as to introduce variations in luminance as a result of the mapping. The mapping and secondary data values (8) are mutually arranged to take account of the signal voltage to on-axis luminance response of the panel (2) so that the luminance variations introduced on-axis tend to balance locally through spatial averaging to, and hence would not be perceivable by, an on-axis viewer (3).

Abstract: Network services systems and methods are provided. A particular system includes an information store including connection information to initiate connections to content sources. The connection information includes an address and a connection rule associated with a video content source. The system includes an access engine to receive a request for an information stream output by the video content source from a user device. The system also includes a services engine to retrieve the connection rule from the information store and to initiate establishment of at least a portion of a point to point protocol communication link between the user device and the video content source in accordance with the connection rule. The system includes a metrics engine to track a metric associated with the point to point protocol communication link and to generate a billing record at least partially based upon the metric.

Abstract: A system and method for providing managed point-to-point services are disclosed. In one embodiment of a system incorporating teachings of the present disclosure, a services management center may be capable of receiving a request for connection to a video content source. A requesting user may be part of one managed network and the content source may be part of another network. The content source may be able output an information stream. In operation, the center may determine an address for the video content source and initiate the formation of at least a portion of a point-to-point communication link between the requesting user and the video content source. In some embodiments, the center may be able to track a metric associated with communication of the information stream and may generate a billing record at least partially based upon the metric.