Patents by Inventor Roger B. Clark

Roger B. Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrolides with Modified Desosamine Sugars and Uses Thereof
    Publication number: 20230242565
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Application
    Filed: April 4, 2023
    Publication date: August 3, 2023
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • Macrolides with modified desosamine sugars and uses thereof
    Patent number: 11673910
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 13, 2023
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20230122651
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 12, 2022
    Publication date: April 20, 2023
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plarnondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof
    Publication number: 20230093692
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 23, 2023
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Hogan Philip, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Andre Sanchez, Ganapathy Dhandapani, Thrimurtulu Neetipalli, Md. Ataur Rahman, Thomas Lepitre
  • Macrolides with Modified Desosamine Sugars and Uses Thereof
    Publication number: 20220306673
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Application
    Filed: April 27, 2018
    Publication date: September 29, 2022
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra llandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
    Publication number: 20220177508
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: November 18, 2019
    Publication date: June 9, 2022
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Vijaya Gondi, Philip Hogan, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Md. Ataur Rahman
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20210122709
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: June 10, 2020
    Publication date: April 29, 2021
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Tetracycline compounds
    Patent number: 10913712
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: February 9, 2021
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20200055813
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 20, 2020
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • TETRACYCLINE COMPOUNDS
    Publication number: 20200048193
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • Tetracyline compounds
    Patent number: 10315992
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 11, 2019
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • TETRACYCLINE COMPOUNDS
    Publication number: 20190077803
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Application
    Filed: May 2, 2018
    Publication date: March 14, 2019
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20190002398
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: January 29, 2018
    Publication date: January 3, 2019
    Inventors: Jingye Shanghai, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Tetracycline compounds
    Patent number: 10072007
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 11, 2018
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn
  • Tetracyline Compounds
    Publication number: 20170305852
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Application
    Filed: January 6, 2017
    Publication date: October 26, 2017
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • C7-Fluoro Substituted Tetracycline Compounds
    Publication number: 20170275244
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: November 9, 2016
    Publication date: September 28, 2017
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana Katharine Hunt, Roger B. Clark, Robert Zahler
  • NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170136007
    Abstract: Disclosed are novel piperazine derivatives that act as agonists of the a7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
    Type: Application
    Filed: August 26, 2016
    Publication date: May 18, 2017
    Inventors: ROGER B. CLARK, DANIEL ELBAUM
  • Polycyclic Tetracycline Compounds
    Publication number: 20170107179
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
    Type: Application
    Filed: May 25, 2016
    Publication date: April 20, 2017
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Magnus P. Ronn, Louis Plamondon, Minsheng He, Joyce A. Sutcliffe, Trudy Grossman
  • Tetracycline compounds
    Patent number: 9573895
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: February 21, 2017
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • TETRACYCLINE COMPOUNDS
    Publication number: 20170044160
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Application
    Filed: March 24, 2016
    Publication date: February 16, 2017
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn