Abstract: A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.

Abstract: A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.

Abstract: A medical device material impregnated with a combination of antimicrobial agents, the combination of antimicrobial agents comprising a first antimicrobial agent, the first antimicrobial agent being triclosan and at least a second antimicrobial agent, wherein the combination of antimicrobial agents provides the device material with antimicrobial activity and inhibition of resistant microbial mutations for of the order of, or greater than, 80 days.

Abstract: A method of impregnating a polymeric substrate with an antimicrobial substance or precursor thereto, in which said substance is impregnated into said substrate as a solution, an emulsion or a suspension in a supercritical fluid. Additionally, there is provided a method of impregnating a substantially transparent polymeric substrate with an antimicrobial substance or precursor thereto, wherein the polymeric substrate is capable of being swelled by a swelling agent which contains dissolved, suspended or emulsified therein said antimicrobial substance or precursor thereto, so as to permit impregnation of the polymeric substrate with the antimicrobial substance or precursor thereto. There is also provided a device obtained by such methods.

Abstract: A medical device made from a material capable of being implanted in living tissue or transcutaneously inserted therein or of long term in-dwelling therein, which exhibits persistent antimicrobial activity in use, and containing a body of a synthetic or naturally occurring material having side surfaces and being capable of being swelled by penetration of a swelling agent and which has been subjected to such a swelling agent which contains completely dissolved therein at least one antimicrobial agent as a solute, the surfaces being contacted by such swelling agent for a sufficient period of time to promote swelling of the matrix of a body of material and thereby permit diffusion and migration of the solution containing the selected antimicrobial agent solute into the interstitial spaces of the body of material at the molecular level by the action of the swelling agent within the body of material, and the solvent being capable of being removed from the solute in the body of material by evaporation and after remo