Abstract: Systems, devices, and methods for optimizing a physiological measurement are described herein. A system may include a wearable band that is wearable by a subject, a user device attached to the wearable band, and a measurement device configured to the physiological measurement. The user device may include a first communication device and a user interface. The measurement device may include a hollow housing, a processing device disposed within the housing, an elastic coupling member disposed within the housing, a physiological sensor coupled to the housing by the elastic coupling member, and a second communication device. The physiological sensor may take the physiological measurement and communicate the physiological measurement to the user device. The user interface may display the physiological measurement to the subject. The physiological measurement device and the user device may be attached to the same wearable band that is worn by the subject.

Abstract: Systems, devices, and methods are described herein for maintaining a physiological sensor at constant pressure against a subject. A system may include a wearable band that is wearable by a subject, a physiological sensor coupled to the wearable band, a pressure sensor coupled to the wearable band, a processor and a user interface. The physiological sensor may be positioned along an inside surface of the wearable band, embedded in the wearable band, or otherwise positioned in the band to be adjacent to the subject as the subject wears the wearable band. The pressure sensor may directly or indirectly measure a pressure of the physiological sensor against the subject. The processor may generate an alert when a pressure measurement for the physiological sensor against the subject is outside a specified range. The user interface may present the alert to the subject.

Abstract: Systems, devices, and methods are described herein for ensuring constant contact of a physiological sensor with a subject. A device may include a wearable band wearable by the subject, an elastic coupling member, a sensor module coupled by the elastic coupling member to the wearable band, a housing attached to the wearable band, a processor, and a user interface. The wearable band may include a recess extending into the wearable band. The elastic coupling member and/or the sensor module may be disposed within the recess. As the subject wears the wearable band, the elastic coupling member may press the sensor module against the subject and may cause constant contact between the sensor module and the subject. Electrical tracing embedded in the wearable band and extending from the sensor module to the housing may couple the sensor module to the processor or the user interface.

Abstract: An adjustable measurement device is described that may include a housing, a power supply, a processor, a communication device, an elastic coupling member, a physiological sensor, and/or a clamp. The housing may be configured to attach to a wearable band that is wearable by a subject. The housing may include a chamber within the housing. The power supply, the processor, the communication device, the elastic coupling member, and or the physiological sensor may be disposed within the chamber. The elastic coupling member may couple the physiological sensor to the housing. A force exerted by the elastic coupling member on the physiological sensor may be in a direction through an opening towards a body part of a subject. As the subject wears the wearable band and the housing is coupled to the wearable band, the physiological sensor may be adjacent to or contact the subject.

Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.

Abstract: A cathode ray display tube has a mild steel envelope part (10) with a tubular copper pump stem (20) sealingly attached thereto by friction welding. A method of attaching the pump stem involves forming the pump stem initially with a closed end, rotating the pump stem relative to and against the mild steel envelope part and applying pressure to cause friction welding of the pump stem, and thereafter extending the pump stem's bore through its closed end by drilling. A hole may simultaneously be drilled through the envelope part. The friction weld provides reliable vacuum-tightness and strength, and the attachment of the pump stem in this manner can be accomplished using automation quickly and inexpensively.

Abstract: A tamper-resistant package for articles such as pharmaceuticals and medicine which are themselves first enclosed within a first closed and sealed container. The first container is then enclosed within a second container, there being a void between the two containers. The second container includes a lid which is secured over its opening. Positioned between the lid and the opening of the second container is a permanently adhered thin sheet of elastic material or membrane which is impermeable to gas or liquid. This membrane is permanently adhered to the opening of the second container after the sealed first container and a portion of solid chemical material possessing the physical property of sublimation is placed into the void.