Patents by Inventor Roger Bookland

Roger Bookland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted cyclic amine metalloprotease inhibitors
    Publication number: 20050154019
    Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Inventors: Michael Natchus, Biswanath De, Stanislaw Pikul, Neil Almstead, Roger Bookland, Yetunde Taiwo, Menyan Cheng
  • Substituted cyclic amine metalloprotease inhibitors
    Publication number: 20050137248
    Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: February 16, 2005
    Publication date: June 23, 2005
    Inventors: Michael Natchus, Biswanath De, Stanislaw Pikul, Neil Almstead, Roger Bookland, Yetunde Taiwo, Menyan Cheng
  • Substituted cyclic amine metalloprotease inhibitors
    Publication number: 20050101567
    Abstract: The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: December 3, 2004
    Publication date: May 12, 2005
    Inventors: Michael Natchus, Biswanath De, Stanislaw Pikul, Neil Almstead, Roger Bookland, Yetunde Taiwo, Menyan Cheng
  • Bradyrhizobium japonicum nodulation inducing factor
    Patent number: 5229113
    Abstract: The chemical compounds that induce expression of nodulation genes of Bradyrhizobium japonicum strains have been identified. The isoflavones daidzein and genistein were identified as soybean exudate components that induce nod-genes. Other isoflavones, including 7-hydroxyisoflavone, 5,7-dihydroxyisoflavone, biochanin A, formononetin and prunetin, were also found to act as inducers. In addition, several flavonoid compounds including 4',7-dihydroxyflavone, apigenin, kaempferol and coumestrol, were also found to act as inducers. Nodulation inducing compositions and a method for selectively activating the expression of a gene under the control of a soybean exudate inducible promoter in B. japonicum in response to these inducer molecules are described. In addition, soybean inoculating compositions containing the nod-gene inducers and inoculating methods employing these compositions are described.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: July 20, 1993
    Assignee: Lubrizol Genetics, Inc.
    Inventors: Renee Kosslak, Roger Bookland, Edward R. Appelbaum