Patents by Inventor Roger Brooke
Roger Brooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170102385Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: December 19, 2016Publication date: April 13, 2017Applicant: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Patent number: 9535064Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: GrantFiled: March 1, 2013Date of Patent: January 3, 2017Assignee: SANOFI PASTEUR LIMITEDInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Publication number: 20150316567Abstract: This disclosure relates to methods for detecting the potency of a drug preparation and/or detecting antibodies in a host reactive against one or more antigens.Type: ApplicationFiled: December 13, 2014Publication date: November 5, 2015Applicant: SANOFI PASTEUR LIMITEDInventors: Marie-Danielle Salha, Scott Gallichan, Roger Brookes, Martina Ochs-Onolemhemhen
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Publication number: 20140349863Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: March 1, 2013Publication date: November 27, 2014Applicant: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Patent number: 8404457Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: GrantFiled: February 2, 2009Date of Patent: March 26, 2013Assignee: Sanofi Pasteur LimitedInventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrist
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Patent number: 8337846Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.Type: GrantFiled: July 23, 2008Date of Patent: December 25, 2012Assignee: Sanofi Pasteur LimitedInventors: Martina Ochs, Roger Brookes, Robert Charlebois, Jeremy Yethon
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Publication number: 20110130300Abstract: Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.Type: ApplicationFiled: February 2, 2008Publication date: June 2, 2011Inventors: Martina Ochs-Onolemhemhen, Roger Brookes, Claire-Anne Siegrest
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Publication number: 20100297133Abstract: Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.Type: ApplicationFiled: July 23, 2008Publication date: November 25, 2010Inventors: Martina Ochs, Roger Brookes, Robert Charlebois, Jeremy Yethon
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Publication number: 20040037837Abstract: Use of (a) a polypeptide which comprises an epitope sequence of the formula (I): X1 L/I/M X2 X3 X4 X5 X6 X7 V/L/I wherein X1 is G, X2 is P, X3 is V, X4 is E, X5 is Y, X6 is L and X7 is Q, or X1 is K or R, X2 is I or V, X3 is A, X4 is N, X5 is N, X6 is T and X7 is R, or an epitope sequence which is an analogue of (I) and which can be recognised by a CD8 T cell that recognises (I); or (b) an expression vector comprising a polynucleotide encoding a said polypeptide (a) operably linked to a regulatory sequence capable of providing for expression of the said polypeptide (a); for use in the manufacture of a medicament for vaccinating prophylactically or therapeutically against infection by a mycobacterium by stimulating a CD8 T cell response. Also provided are polypeptides, expression vectors and cells which can be used to treat mycobacterial infections; and a method of detecting T cells that can recognise the epitope defined above.Type: ApplicationFiled: May 21, 2003Publication date: February 26, 2004Inventors: Hazel Marguerite Dockrell, Steven Mark Smith, Roger Brookes
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Patent number: 4100732Abstract: Airflow exiting a centrifugal compressor is diffused in multiple shaped passages tangential to the compressor impeller dumped into a plenum to reduce its Mach number and then directed through deswirl vanes to the entrance of a combustor. Deswirl at reduced Mach number significantly reduces pressure losses resulting in reduced complexity and manufacturing cost for the diffuser deswirl system.Type: GrantFiled: December 2, 1976Date of Patent: July 18, 1978Assignee: General Electric CompanyInventors: Alexander Connor Bryans, Barry Weinstein, Neil Roger Brookes, John William Vdoviak
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Patent number: 4089848Abstract: A process for the extraction of food values from oats is disclosed. Acid-soluble protein may be obtained by de-oiling comminuted groats, treating the de-oiled groats with an aqueous solution of pH 9.5-11.5, acidifying the alkaline solution after separation of insoluble material to a pH of 1.8-3.2, preferably 2.2-2.8, and separating acid-soluble protein from the acidified solution after separation of insoluble material. Each step in the process is controlled so as to minimize denaturing of acid-soluble protein. Techniques for separation of acid-soluble protein from the acidified solution are disclosed. The separation of other protein products, bran, flour and gum is also disclosed. The use of protein products as emulsifying agents is disclosed.Type: GrantFiled: February 2, 1976Date of Patent: May 16, 1978Assignee: Du Pont of Canada LimitedInventors: Albert Bell, John Roger Brooke Boocock, Richard Walton Oughton
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Patent number: 4053492Abstract: A process for the extraction of oil from oats is disclosed. The process comprises extracting oil from comminuted oats with 2-propanol and separating the resultant 2-propanol solution from the de-oiled oats. Oat oil is recoverable from the 2-propanol solution. The 2-propanol may be in the form of an azeotropic mixture of 2-propanol and water. In a preferred embodiment the 2-propanol contains a minor amount e.g. 0.1- 1.0%, of hydrogen peroxide. The process is capable of producing a clear, lightly colored oil from oats. The oil is believed useful as a vegetable oil.Type: GrantFiled: February 2, 1976Date of Patent: October 11, 1977Assignee: Du Pont of Canada Ltd.Inventors: John Roger Brooke, Richard Walton Oughton
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Patent number: 4047379Abstract: In a gas turbine engine of the type which includes an inlet particle separator, there is provided apparatus for measuring the temperature of the air entering the engine compressor.A remote temperature probe is disposed in a feed duct having an inlet in flow communication with the engine inlet upstream of the particle separator and an outlet disposed intermediate the particle separator and inlet to the engine compressor. Airflow through the feed duct is generated by the pressure drop across the particle separator without the use of compressor bleed or other air sources which result in performance degradation of the engine. Temperature measurement errors during engine anti-icing are reduced by selectively cross-bleeding a predetermined quantity of anti-icing air into the feed duct during activation of the engine's anti-icing system. The response rate of the probe is significantly improved by enclosing the probe in an impingement heat transfer blanket.Type: GrantFiled: April 28, 1976Date of Patent: September 13, 1977Assignee: General Electric CompanyInventors: Neil Roger Brookes, Martin George Ray, Joseph David Cohen, Thomas Joseph McCarey
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Patent number: D368527Type: GrantFiled: June 22, 1994Date of Patent: April 2, 1996Assignee: Hollister Inc.Inventor: Roger Brooke
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Patent number: D379232Type: GrantFiled: February 26, 1996Date of Patent: May 13, 1997Assignee: Hollister IncorporatedInventor: Roger Brooke