Abstract: Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2,X is oxygen and Y is sulfur or sulfonyl or X and Y are both sulfur or sulfonyl, andHet is a 5- or 6-membered heterocyclic radical having from 1 to 3 hetero atoms inclusive selected from nitrogen and sulfur and optionally substituted by one or more alkyl each having from 1 to 5 carbon atoms inclusive.These compounds may be used as medicines, especially in the treatment of central nervous system disorders and Parkinson's disease.

Abstract: Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl,X is nitrogen and simultaneously Y is oxygen or sulfur, orX is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, andR is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl.These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.

Abstract: Pharmaceutical compositions containing as active principle a .gamma.-resorcylic acid derivative of the formula: ##STR1## or a physiologically tolerable salt thereof. These pharmaceutical compositions are used especially in the treatment of thromboembolic diseases and arteriosclerosis.

Abstract: Naphthyl derivatives of the formula: ##STR1## wherein: R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, andR.sub.2 and R.sub.3, which are the same or different, are hydrogen, lower alkyl or phenyl,Or R.sub.2 and R.sub.3 joined together are --CH .dbd. CH -- CH .dbd. CH--.These compounds are used as medicines, especially in the treatment of disorders of central nervous system (CNS), Parkinson's disease and cardiovascular disorders.

Abstract: Heterocyclic compounds of the formula: ##STR1## WHEREIN ONE OF Y and Z is CH, the other being N, A is a straight or branched saturated hydrocarbon chain from C.sub.2 to C.sub.6 inclusive, X is chlorine, hydroxy, alkoxy or alkylthio each from C.sub.1 to C.sub.5 inclusive, R is hydrogen, alkyl, hydroxyalkyl or dihydroxyalkyl each from C.sub.1 to C.sub.3 inclusive, R' is halogen, alkyl or alkoxy each from C.sub.1 to C.sub.3 inclusive and n is 0, 1 or 2.These compounds, their optical isomers and their physiologically tolerable salts are used as medicines especially in the treatment of central nervous system disorders.

Abstract: Benzodioxole compounds of the formula: vasodilator ##STR1## WHEREIN R.sub.1 is hydrogen, lower alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl,R.sub.2 is lower-alkyl, aryl, haloaryl, lower-alkylaryl, lower-alkoxyaryl, methylenedioxyaryl, ethylenedioxyaryl, trifluoromethylaryl, nitroaryl or aminoaryl, orR.sub.1 + r.sub.2 are --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 -- or --(CH.sub.2).sub.6 -- andHet is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinazolinyl, 1,3,5 triazinyl or 1,3-thiazolyl, each being optionally substituted by lower-alkyl, lower-alkoxy, hydroxyl or phenyl.These compounds are used as medicines especially as peripheral vasocilator agent and central nervous system stimulant.

Abstract: Heterocyclic amides of the formula: ##SPC1##Wherein:X is N or CH;n is O or 1 andR is ##EQU1## or ##SPC2##Wherein:R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

Abstract: Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

Abstract: Piperazine derivatives of the formula: ##SPC1##Wherein n is 0 or 1, X is oxygen or sulfur, R and R', which are the same or different, are hydrogen or lower alkyl and: ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicine especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and pain.

Abstract: Disubstituted piperazines of the formula: ##SPC1##Wherein:n is 1 or 2;X is oxygen or sulfur;R is hydrogen or lower alkyl;Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2##Is always bonded to the benzene ring.These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.