Abstract: Disclosed herein are methods and compositions for the treatment of muscle contractures. In particular, the disclosed methods and compositions may be used to improve longitudinal muscle growth in individuals having muscle contractures, for example, muscle contractures resulting from cerebral palsy or brachial plexus injury. The methods and compositions may employ, for example, the administration of a therapeutic dose of a proteasome inhibitor.

Abstract: Disclosed are compositions and methods for treatment of an individual having a muscle contracture. The method may include the step of administering nandrolone or a pharmaceutically acceptable salt thereof to the individual in need thereof. The muscle contracture may result from a disorder selected from neonatal brachial plexus injury, cerebral palsy, or a combination thereof. Articles of manufacture containing nandrolone are also disclosed.