Abstract: A scalpel blade remover in which the blade is clamped against a fixed block by manipulating a lever to cause a movable block to move toward the fixed block. The movable block is preferably made of resilient material and all other elements of the structure are made of metal such as stainless steel, all components being autoclavable. A tab is provided on the movable block to engage an end of the blade and move that end relative to the body of the blade and the scalpel handle to disengage the blade from the handle. The blocks are mounted upon a supporting surface, beneath which a sterile disposable box may be disposed. The supporting surface is slotted in a plane which includes the area of clamping of the scalpel blade between the fixed and movable blocks. The movable block may also be provided with a guide portion to ensure the clamping action, and the movable block may be provided with a relieved or cut-off end permitting a scalpel blade to be disengaged from the scalpel handle.