Patents by Inventor Roger F. Bone

Roger F. Bone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Patent number: 6036920
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: March 14, 2000
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • System, method, and computer program product for at least partially automatically generating chemical compounds with desired properties from a list of potential chemical compounds to synthesize
    Patent number: 5901069
    Abstract: A computer based, iterative process for generating chemical entities with defined physical chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: May 4, 1999
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Dimitris K. Agrafiotis, Roger F. Bone, Francis R. Salemme, Richard M. Soll
  • Guanidino protease inhibitors
    Patent number: 5792769
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 --R.sup.4, R.sup.7 --R.sup.8, R.sup.a, R.sup.b, R.sup.c, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: August 11, 1998
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Tianbao Lu, Carl R. Illig, Bruce E. Tomczuk, Richard M. Soll, Nalin L. Subasinghe, Roger F. Bone
  • System, method, and computer program for at least partially automatically generating chemical compounds having desired properties
    Patent number: 5684711
    Abstract: A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: November 4, 1997
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Dimitris K. Agrafiotis, Roger F. Bone, Francis R. Salemme, Richard M. Soll
  • Thrombin inhibitors
    Patent number: 5612369
    Abstract: The present invention is directed to novel compounds that are thrombin inhibitors and are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The compounds have the general Formula I: ##STR1## and pharmaceutically acceptable salts thereof; wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n and m are defined herein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 18, 1997
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Roger F. Bone, Richard M. Soll, Carl L. Illig, Tianbao Lu, Nalin L. Subasinghe
  • System and method of automatically generating chemical compounds with desired properties
    Patent number: 5574656
    Abstract: A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: November 12, 1996
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Dimitris K. Agrafiotis, Roger F. Bone, Francis R. Salemme, Richard M. Soll
  • System and method of automatically generating chemical compounds with desired properties
    Patent number: 5463564
    Abstract: A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: October 31, 1995
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Dimitris K. Agrafiotis, Roger F. Bone, Francis R. Salemme, Richard M. Soll