Abstract: A device for separating a signal from noise and background contribution, particularly for computerized electrochemical instruments. It comprises an experimental data manipulator circuit; an ordering processor connected to the manipulator and arranged to provide the manipulator with the rules for the correct formatting of the experimental data, on the basis of selective operative modes; a command sequencer circuit, which governs the operation of the device on the basis of the values of the characteristic parameters for each mode; an interpolator circuit which execute the selective operative modes and recalculates each formatted data item using algorithms based on interpolation polynominals calculated by the Newton divided differences formula and the Aitken scheme for accelerating the calculation.