Patents by Inventor Roger G. Little, II

Roger G. Little, II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic uses of bactericidal/permeability increasing protein products
    Patent number: 5837678
    Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 17, 1998
    Assignee: XOMA Corporation
    Inventor: Roger G. Little, II
  • Therapeutic uses of bactericidal/permeability increasing protein (BPI) protein products
    Patent number: 5807818
    Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: September 15, 1998
    Assignee: Xoma Corporation
    Inventor: Roger G. Little, II
  • Anti-gram-positive bacterial methods and materials
    Patent number: 5783561
    Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: July 21, 1998
    Assignee: XOMA Corporation
    Inventors: Arnold Horwitz, Lewis H. Lambert, Jr., Roger G. Little, II
  • Modified antibody variable domains
    Patent number: 5766886
    Abstract: Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.
    Type: Grant
    Filed: August 13, 1993
    Date of Patent: June 16, 1998
    Assignee: Xoma Corporation
    Inventors: Gary M. Studnicka, Roger G. Little, II, Dianne M. Fishwild, Fred R. Kohn
  • Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
    Patent number: 5652332
    Abstract: The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: July 29, 1997
    Assignee: XOMA
    Inventor: Roger G. Little, II
  • Therapeutic uses of bactericidal/permeability increasing protein products
    Patent number: 5639727
    Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: June 17, 1997
    Assignee: XOMA Corporation
    Inventor: Roger G. Little, II
  • Anti-fungal methods and materials
    Patent number: 5627153
    Abstract: The present invention relates to methods for treating fungal infection comprising administering to a subject suffering from a fungal infection a bactericidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: May 6, 1997
    Assignee: Xoma Corporation
    Inventors: Roger G. Little, II, Edward Lim, Patrick J. Scannon, Lewis J. Lambert, Jr.
  • Anti-gram-positive bacterial methods and materials
    Patent number: 5578572
    Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: November 26, 1996
    Assignee: Xoma Corporation
    Inventors: Arnold Horwitz, Lewis H. Lambert, Jr., Roger G. Little, II
  • Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
    Patent number: 5523288
    Abstract: The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: June 4, 1996
    Assignee: Xoma Corporation
    Inventors: Jonathan Cohen, Ada H. C. Kung, Lewis H. Lambert, Jr., Roger G. Little, II
  • Therapeutic uses of bactericidal/permeability increasing protein products
    Patent number: 5348942
    Abstract: The present invention provides therapeutic methods for treatment of conditions including the neutralization of the anti-coagulant activity of heparin, inhibition of angiogenesis, tumor and endothelial cell proliferation, and treatment of chronic inflammatory diseases by administration of bactericidal/permeability-increasing (BPI) protein products.
    Type: Grant
    Filed: March 12, 1993
    Date of Patent: September 20, 1994
    Assignee: Xoma Corporation
    Inventors: Roger G. Little, II, Helene Gazzano-Santoro, James B. Parent