Patents by Inventor Roger Giles

Roger Giles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12176198
    Abstract: A device (1) for manipulating charged particles, the device comprising a series of electrodes (2, 3) that form a channel for transportation of the charged particles. A power supply unit (5, 6) provides a voltage to axially segmented bunching electrodes to create a potential well within the channel having one or more local minima between local maxima (50, 51). The well is translated along the channel. An axial extraction region (54) comprises electrodes defining an end of the channel. They receive a supply voltage to create a pseudo-potential within the channel such that the depth of the potential well varies according to the mass-to-charge ratio (m/z) of the charged particles transported therein and reduces as a local maxima of the potential well is translated axially towards the axial extraction region thereby to release the transported charged particles of different mass-to-charge ratio (m/z) at different respective times.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: December 24, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Alina Giles
  • Patent number: 12057305
    Abstract: A device (1) for manipulating charged particles, the device comprising a series of electrodes (2, 3) disposed so as to form a channel for transportation of the charged particles. A power supply unit (5) provides a first supply voltage (7) which changes according to a waveform having a period (T), to axially segmented bunching electrodes (3) to create an electric field within the channel. The potential of the electric field defines a potential well which is translated along the length of the channel such that the potential well is translated a distance substantially equal to its length in an interval of time substantially equal to the period (T). The waveform is substantially continuously smooth throughout its period (T); and, substantially constant in value throughout a finite duration of time (TL<T) within the period (T), corresponding to a minimum of the waveform.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: August 6, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Alina Giles
  • Patent number: 11581173
    Abstract: An apparatus for analysing ions, including a first mass analyser configured to eject groups of ions in a predetermined sequence during different time windows; an ion transport device having a plurality of electrodes arranged around a transport channel; control means configured to control voltages applied to the electrodes to generate a transport potential in a transport channel, the transport potential having a plurality of potential wells configured to move along the transport channel such that each group of ions received by the ion transport device is respectively transported along the transport channel by one or more selected potential; fragmentation means configured to fragment precursor ions in each group of ions so as to produce product ions; and a second mass analyser configured to produce a respective mass spectrum using each group of ions after the group of ions has been fragmented and transported.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: February 14, 2023
    Assignee: SHIMADZU CORPORATION
    Inventors: Alina Giles, Roger Giles
  • Patent number: 11428666
    Abstract: A device for performing field asymmetric waveform ion mobility spectrometry, “FAIMS” including first and second segmented planar electrodes, each electrode including three or more segments and extending in a direction parallel to an analytical axis of the device, the first and second segmented electrodes are separated from each other to provide an analytical gap therebetween; and propelling means for propelling ions through the analytical gap in a direction parallel to the analytical axis. The device is configured to operate in: a FAIMS mode in which a power supply applies voltage waveforms to the segments to produce an asymmetric time dependent electric field in the analytical gap for FAIMS analysis of ions propelled through the analytical gap; and a transparent mode in which the power supply applies voltage waveforms to the to produce a confining electric field in the analytical gap for focussing ions towards the longitudinal axis.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: August 30, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Roch Andrzejewski
  • Patent number: 11227757
    Abstract: A device for performing field asymmetric waveform ion mobility spectrometry, “FAIMS,” including first and second segmented planar electrodes, each electrode including three or more segments and extending in a direction parallel to an analytical axis of the device, wherein the first and second segmented electrodes are separated from each other to provide an analytical gap therebetween; and propelling means for propelling ions through the analytical gap in a direction parallel to the analytical axis. The device is configured to operate in a FAIMS mode in which a power supply applies voltage waveforms to the segments to produce an asymmetric time dependent electric field in the analytical gap for FAIMS analysis of ions propelled through the analytical gap. The asymmetric time dependent electric field has substantially straight contours of equal field strength in a plane perpendicular to the analytical axis to focus ions having different differential mobilities towards different spatial domains.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: January 18, 2022
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Roch Andrzejewski
  • Patent number: 10964518
    Abstract: An apparatus for transporting charged particles. The apparatus includes a control unit and a transport device having a plurality of electrodes arranged around a transport channel, wherein the transport channel includes a bunch forming region configured to receive charged particles received by the transport device. The control unit is configured to control voltages applied to the electrodes to generate a transport potential in the transport channel, the transport potential having a plurality of potential wells which are configured to move so as to transport charged particles along the transport channel in one or more bunches.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: March 30, 2021
    Assignee: SHIMADZU CORPORATION
    Inventors: Matthew Gill, Roger Giles, Alina Giles
  • Publication number: 20210066061
    Abstract: A device for performing field asymmetric waveform ion mobility spectrometry, “FAIMS,” including first and second segmented planar electrodes, each electrode including three or more segments and extending in a direction parallel to an analytical axis of the device, wherein the first and second segmented electrodes are separated from each other to provide an analytical gap therebetween; and propelling means for propelling ions through the analytical gap in a direction parallel to the analytical axis. The device is configured to operate in a FAIMS mode in which a power supply applies voltage waveforms to the segments to produce an asymmetric time dependent electric field in the analytical gap for FAIMS analysis of ions propelled through the analytical gap. The asymmetric time dependent electric field has substantially straight contours of equal field strength in a plane perpendicular to the analytical axis to focus ions having different differential mobilities towards different spatial domains.
    Type: Application
    Filed: July 29, 2020
    Publication date: March 4, 2021
    Applicant: SHIMADZU CORPORATION
    Inventors: Roger Giles, Roch Andrzejewski
  • Patent number: 10770279
    Abstract: An ion transfer apparatus for transferring ions from an ion source at an ion source pressure, which ion source pressure is greater than 500 mbar, along a path towards a mass analyser at a mass analyser pressure that is lower than the ion source pressure. The apparatus includes a plurality of pressure controlled chambers, wherein each pressure controlled chamber in the ion transfer apparatus includes an ion inlet opening for receiving ions from the ion source on the path and an ion outlet opening for outputting the ions on the path. The plurality of pressure controlled chambers are arranged in succession along the path from an initial pressure controlled chamber to a final pressure controlled chamber, wherein an ion outlet opening of each pressure controlled chamber other than the final pressure controlled chamber is in flow communication with the ion inlet opening of a successive adjacent pressure controlled chamber.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 8, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Alina Giles
  • Patent number: 10600631
    Abstract: An ion trap having a segmented electrode structure having a plurality of segments consecutively positioned along an axis, wherein each segment of the segmented electrode structure includes a plurality of electrodes arranged around the axis. A first voltage supply is configured to operate in a radially confining mode in which at least some electrodes belonging to each segment are supplied with at least one AC voltage waveform so as to provide a confining electric field for radially confining ions within the segment. A second voltage supply is configured to operate in a trapping mode in which at least some of the electrodes belonging to the segments are supplied with different DC voltages so as to provide a trapping electric field that has an axially varying profile for urging ions towards and trapping ions in a target segment of the plurality of segments. A first chamber is configured to receive ions from an ion source, wherein a first subset of the segments are located within the first chamber.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 24, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Matthew Clive Gill
  • Patent number: 10559454
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: February 11, 2020
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Patent number: 10431443
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: October 1, 2019
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Publication number: 20190122875
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 25, 2019
    Applicant: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander BERDNIKOV, Alina Andreyeva, Roger Giles
  • Patent number: 10269549
    Abstract: A time of flight (“TOF”) mass spectrometer including an ion source, a detector, and a tilt correction device. The ion source is configured to produce ions having a plurality of m/z values. The detector detects ions produced by the ion source. The tilt correction device is located along a portion of a reference ion flight path extending from the ion source to a planar surface of the detector and includes tilt correction electrodes configured to generate at least one dipole electric field across the reference ion flight path. The at least one dipole electric field is configured to tilt an isochronous plane of ions produced by the ion source so as to correct a previous angular misalignment between the isochronous plane and the planar surface of the detector.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: April 23, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Hamish Ian Stewart, Matthew Gill, Roger Giles
  • Patent number: 10186407
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: January 22, 2019
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Patent number: 9892899
    Abstract: An ion manipulation device for guiding or confining ions in an ion processing apparatus. The device has a first circuit board, wherein at least one first electrode for manipulating the path of ions is mounted on a mounting surface of the first circuit board; a second circuit board, wherein at least one second electrode for manipulating the path of ions is mounted on a mounting surface of the second circuit board; at least one bridging electrode for manipulating the path of ions, wherein the at least one bridging electrode is mounted to both the mounting surface of the first circuit board and the mounting surface of the second circuit board, wherein the bridging electrode is configured to hold the first circuit board and the second circuit board apart from each other in a fixed spatial relationship in which the mounting surface of the second circuit board faces towards the mounting surface of the first circuit board.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: February 13, 2018
    Assignee: SHIMADZU CORPORATION
    Inventors: Matthew Clive Gill, Roger Giles
  • Patent number: 9812308
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 7, 2017
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Patent number: 9595432
    Abstract: A time-of-flight mass spectrometer (1) comprises an ion source a segmented linear ion device (10) for receiving sample ions supplied by the ion source and a time-of-flight mass analyzer for analyzing ions ejected from the segmented device. A trapping voltage is applied to the segmented device to trap ions initially into a group of two or more adjacent segments and subsequently to trap them in a region of the segmented device shorter than the group of segments. The trapping voltage may also be effective to provide a uniform trapping field along the length of the device (10).
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 14, 2017
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Michael Sudakov, Hermann Wollnik
  • Patent number: 9536721
    Abstract: The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 3, 2017
    Assignee: Shimadzu Research Laboratory (Europe) Ltd.
    Inventors: Alexander Berdnikov, Alina Andreyeva, Roger Giles
  • Patent number: 9136100
    Abstract: A time of flight analyzer that comprises a pulsed ion source; a non-linear ion mirror having a turn-around point; and a detector. The pulsed ion source is configured to produce an ion pulse travelling along an ion flight axis, the ion pulse comprising an ion group consisting of ions of a single m/z value, the ion group having a lateral spread. The non-linear ion mirror is configured to reflect the ion group, at the turn-around point, along the ion flight axis towards the detector, the passage of the ion group through the non-linear ion mirror causing a spatial spread of the ion group. The time of flight mass analyzer has at least one lens positioned between the ion source and the ion mirror, wherein the or each lens is configured to reduce said lateral spread so as to provide a local minimum of lateral spread within the ion mirror.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: September 15, 2015
    Assignee: SHIMADZU CORPORATION
    Inventors: Roger Giles, Matthew Clive Gill
  • Patent number: 9082602
    Abstract: A mass analyzer for use in a mass spectrometer. The mass analyzer has a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference plane and that curves around a reference axis so that, in use, the set of electrodes provide a 3D electrostatic field region. The mass analyzer is configured so that, in use, the 3D electrostatic field region provided by the set of electrodes guides ions having different initial coordinates and velocities along a single predetermined 3D reference trajectory that curves around the reference axis.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: July 14, 2015
    Assignee: SHIMADZU CORPORATION
    Inventors: Vyacheslav Shchepunov, Roger Giles