Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.

Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.

Abstract: The disclosure relates to a cartridge assembly for a drug delivery device, the cartridge assembly comprising a cartridge containing a drug; a cartridge holder, the cartridge holder defining an interior cartridge holding section, where the cartridge is arranged within the cartridge holding section, wherein the cartridge holder comprises a distal region with a needle connector arranged at a distal end of the distal region and a main body region; a fixing feature which is arranged at the distal region; and a region with reduced mechanical stiffness compared to the stiffness of the main body region, the region with reduced mechanical stiffness being integrated into the distal region and arranged between the needle connector and the fixing feature, such that when the cartridge is moved in a proximal direction, an emerging load is transferred from the cartridge to the fixing feature and to the main body region in the proximal direction.

Abstract: A compact setting tool that sets a packer or bridge plug in a wellbore and then self bleeds the gas pressure prior to pulling the string out of the wellbore.

Abstract: A compact setting tool that sets a packer or bridge plug in a wellbore and then self bleeds the gas pressure prior to pulling the string out of the wellbore.

Abstract: A compact setting tool that sets a packer or bridge plug in a wellbore and then self bleeds the pressure prior to pulling the string out of the wellbore.

Abstract: An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.

Abstract: The present invention relates to a display arrangement for an injection device for displaying the size of a dose of a medicament, the display arrangement comprising: a housing (60) providing a rotation axis (3) extending in an axial direction (4), a first display member (22) rotatably supported inside the housing (60) with regard to the rotation axis (3) and having at least one cam (32) radially offset from the rotation axis (3), a second display member (24) rotatably supported inside the housing (60) with regard to the rotation axis (3) and arranged axially adjacent to the first display member (24), a coupling member (26) rotatably engaged with the second display member (24), wherein the coupling member (26) is engaged with the at least one cam (32) of the first display member (22) when the first display member (22) is in a predefined angular position or angular range, wherein the coupling member (26) and the first display member (22) are mutually engaged via a retaining arrangement (48) when the cam (32)

Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.

Abstract: A compact setting tool that sets a packer or bridge plug in a wellbore and then self bleeds the pressure prior to pulling the string out of the wellbore.

Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.

Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.

Abstract: A setting tool for use in setting bridge plugs comprising a piston rod using an improved fastener design to the lower piston to prevent warping of the piston rod when setting.

Abstract: A dispenser head for an aerosol can and a method of assembly of the same, the dispenser head comprising a chassis attached to the associated aerosol can and a spray-through cap attached thereto, the chassis comprising a platform capable of axial movement and a flexible spray channel centrally located thereon.

Abstract: An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.

Abstract: The present invention relates to a A display arrangement for an injection device for displaying the size of a dose of a medicament, the display arrangement comprising: —a housing (60) providing a rotation axis (3) extending in an axial direction (4), —a first display member (22) rotatably supported inside the housing (60) with regard to the rotation axis (3) and having at least one cam (32) radially offset from the rotation axis (3), —a second display member (24) rotatably supported inside the housing (60) with regard to the rotation axis (3) and arranged axially adjacent to the first display member (24), —a coupling member (26) rotatably engaged with the second display member (24), wherein the coupling member (26) is engaged with the at least one cam (32) of the first display member (22) when the first display member (22) is in a predefined angular position or angular range, —wherein the coupling member (26) and the first display member (22) are mutually engaged via a retaining arrangement (48) when the cam

Abstract: A dispenser head for an aerosol can and a method of assembly of the same, the dispenser head comprising a chassis attached to the associated aerosol can and a spray-through cap attached thereto, the chassis comprising a platform capable of axial movement and a flexible spray channel centrally located thereon.

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3 or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, o

Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR?4 and NR?4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R?4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R?4 is H, or R3 and R4 or R?4 together are -A-B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.

Abstract: A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.