Patents by Inventor Roger J. Davis

Roger J. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of ZPR1 as a molecular probe for spinal muscular atrophy
    Publication number: 20020102614
    Abstract: The present invention is based on the discovery that ZPR1 and SMN interact in nuclear gems, and that aberrant interaction between them is associated with spinal muscular atrophy. The invention encompasses methods of diagnosing spinal muscular atrophy, methods of assaying for compounds that affect the interaction between ZPR1 and SMN, and antibodies raised against ZPR1 using a B domain epitope.
    Type: Application
    Filed: November 19, 2001
    Publication date: August 1, 2002
    Inventors: Roger J. Davis, Laxman Gangwani
  • Inhibitors of the JNK signal transduction pathway and methods of use
    Patent number: 6410693
    Abstract: JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the administration of a therapeutically effective amount of JIP-1 polypeptides, peptides, peptide mimetics, or nucleic acids are described.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: June 25, 2002
    Inventors: Roger J. Davis, Martin Dickens
  • Cytokine-stress- and oncoprotein-activated human protein kinase kinases
    Patent number: 6174676
    Abstract: Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human-MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: January 16, 2001
    Assignee: University of Massachusetts
    Inventors: Roger J. Davis, Joel Raingeaud, Benoit Derijard
  • Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases
    Patent number: 6136596
    Abstract: Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: October 24, 2000
    Assignee: University of Massachusetts
    Inventors: Roger J. Davis, Alan Whitmarsh, Cathy Tournier
  • Inhibitors of the JNK signal transduction pathway and methods of use
    Patent number: 6043083
    Abstract: JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the administration of a therapeutically effective amount of JIP-1 polypeptides, peptides, peptide mimetics, or nucleic acids are described.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: March 28, 2000
    Inventors: Roger J. Davis, Martin Dickens
  • Non-activated receptor complex proteins and uses thereof
    Patent number: 5925566
    Abstract: The invention features a substantially pure ZPR1 polypeptide. For example, a ZPR1 polypeptide that specifically binds to a non-activated membrane-bound receptor (e.g., EGF or PDGF receptors) and specifically binds small nucleolar RNAs (e.g., U3). ZPR1 polypeptides can be isolated from any eukaryote, including mammals (e.g. rodents and humans) and fungi (e.g., S. cerevisiae and S. pombe).
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: July 20, 1999
    Assignee: University of Massachusetts
    Inventors: Roger J. Davis, Zoya Galcheva-Gargova
  • Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases
    Patent number: 5736381
    Abstract: Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.
    Type: Grant
    Filed: September 19, 1995
    Date of Patent: April 7, 1998
    Inventors: Roger J. Davis, Shashi Gupta, Joel Raingeaud, Benoit Derijard
  • Measuring system for measuring real time groundwater data
    Patent number: 5553492
    Abstract: A measuring system for measuring real time groundwater data and graphically depicting the data for analysis and interpretation is disclosed. At least one transducer is positioned in a well to be modeled. A control unit is provided to acquire data from the transducer and to store the data acquired. A home base unit is provided to receive data from the control unit. The home base unit contains a geographic information system program for processing the data. A display unit is connected to the home base unit for displaying the data received.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: September 10, 1996
    Assignee: Summit Envirosolutions, Inc.
    Inventors: Daniel P. Barrett, Roger J. Davis, John E. Dustman, Dawn R. Gibas, Bradley G. L. Stevens, Barry T. Wilson