Patents by Inventor Roger J. Tull
Roger J. Tull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4294988Abstract: A method of preparing 2,4-difluoroaniline by reacting 2,4,5-trichloronitrobenzene with a fluorinating agent to form 2,4-difluoro-5-chloronitrobenzene which is then hydrogenated with hydrogen in the presence of a catalyst to form 2,4-difluoroaniline.Type: GrantFiled: October 31, 1977Date of Patent: October 13, 1981Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, Leonard M. Weinstock, Ichiro Shinkai
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Patent number: 4216317Abstract: Adenine is prepared by heating hydrogen chloride and hydrogen cyanide in a mixture of phosphorus oxychloride and dichlorophosphoric acid as solvent in a sealed vessel or by heating N-dichloromethylformamidine hydrochloride or triazine hydrochloride in a mixture of phosphorus oxychloride and dichlorophorphoric acid.Type: GrantFiled: February 12, 1979Date of Patent: August 5, 1980Assignee: Merck & Co., Inc.Inventors: Richard F. Shuman, Roger J. Tull
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Patent number: 4171440Abstract: An efficient method has been found for the removal of the 3-isomer present in crude 9-(2-chloro-6-fluorobenzyl)adenine. Crude 9-(2-chloro-6-fluorobenzyl)adenine is transalkylated in sulfuric acid-toluene to reduce the 3-isomer to undetectable levels (<100 ppm). Alternately, crude 9-(3-chloro-6-fluorobenzyl)adenine is first treated with dilute nitric acid to remove the bulk of the 3-isomer followed by transalkylation to sulfuric acid-toluene to reduce the 3-isomer to undetectable levels (<100 ppm). The overall yield for this purification is about 95% based on the 9-(2-chloro-6-fluorobenzyl)adenine content of the crude material. The resulting pure 9-(2-chloro-6-fluorobenzyl)adenine has anticoccidial activity and is useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.Type: GrantFiled: June 16, 1978Date of Patent: October 16, 1979Assignee: Merck & Co., Inc.Inventors: Ichiro Shinkai, Leonard M. Weinstock, Roger J. Tull
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Patent number: 4167640Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.Type: GrantFiled: July 17, 1978Date of Patent: September 11, 1979Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, David G. Melillo
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Patent number: 4140719Abstract: A method of preparing 2,4-difluoroaniline by reacting 2,4,5-trichloronitrobenzene with a fluorinating agent in the presence of a solid-liquid phase interface, and utilizing a phase transfer catalyst to form 2,4-difluoro-5-chloronitrobenzene, followed by hydrogenation with hydrogen in the presence of a hydrogenation catalyst to form 2,4-difluoroaniline.Type: GrantFiled: October 31, 1977Date of Patent: February 20, 1979Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, Leonard M. Weinstock, Ichiro Shinkai
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Patent number: 4127721Abstract: 9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)-amino[1,2,5]thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.Type: GrantFiled: November 21, 1977Date of Patent: November 28, 1978Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, George D. Hartman, Leonard M. Weinstock
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Patent number: 4123457Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.Type: GrantFiled: September 22, 1976Date of Patent: October 31, 1978Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, David G. Melillo
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Patent number: 4098787Abstract: 9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)amino[1,2,5]thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.Type: GrantFiled: February 14, 1977Date of Patent: July 4, 1978Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, George D. Hartman, Leonard M. Weinstock
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Patent number: 4051144Abstract: Preparation of S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents using as starting material an optically active alkalmine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-where R is hydrogen or an alkali metal)-1,2,5-thiadiazole. Certain3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and certain alkamines and their preparation also are described. Preferred alkamines are S-3,5-disubstituted oxazolidines.Type: GrantFiled: December 4, 1974Date of Patent: September 27, 1977Assignee: Charles E. Frosst & Co.Inventors: Leonard M. Weinstock, Roger J. Tull, Dennis M. Mulvey
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Patent number: 4031125Abstract: Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO-)-1,2,5-thiadiazoles and their preparation also are described.Type: GrantFiled: October 24, 1975Date of Patent: June 21, 1977Assignee: Merck & Co., Inc.Inventors: Leonard M. Weinstock, Roger J. Tull, Dennis M. Mulvey
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Patent number: 3998875Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.Type: GrantFiled: October 2, 1974Date of Patent: December 21, 1976Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, David G. Melillg
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Patent number: 3970693Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl) benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid.This invention relates to new processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid, to intermediates thereof and processes for said intermediates.Type: GrantFiled: July 5, 1974Date of Patent: July 20, 1976Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines
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Patent number: 3962338Abstract: Preparation of an optically active alkamine in the sinister configuration, or a derivative of said alkamine, which is reacted with an 3-X-4-chloro(or RO-- where R is hydrogen or an alkali metal)-1,2,5-thiadiazole to prepare S-3-X-4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazole beta adrenergic blocking agents. Novel 3-morpholino-4-chloro(or RO--)-1,2,5-thiadiazoles and their preparation also are described.Type: GrantFiled: November 19, 1973Date of Patent: June 8, 1976Assignee: Merck & Co., Inc.Inventors: Leonard M. Weinstock, Roger J. Tull, Dennis M. Mulvey
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Patent number: 3944600Abstract: Process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indene-3-acetic acid by reacting fluorobenzene with an acid halide, to form an indanone, reaction of the indanone with a methylthio (or methylsulfinyl)benzyl compound to form 5-fluoro-2-methyl-1-(p-methylthiobenzyl) or (p-methylsulfinylbenzyl)-indene and reacting said indene with a glyoxylic acid. The invention also relates to intermediates thereof and processes for said intermediates.Type: GrantFiled: September 30, 1974Date of Patent: March 16, 1976Assignee: Merck & Co., Inc.Inventors: Roger J. Tull, Robert F. Czaja, Richard F. Shuman, Seemon H. Pines