Patents by Inventor Roger K. Wolff

Roger K. Wolff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions related to a BRAF mutation and microsatellite stability
    Patent number: 10144970
    Abstract: Disclosed are methods and compositions related to a BRAF mutation and microsatellite stability.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: December 4, 2018
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Wade S. Samowitz, Martha L. Slattery, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 8257927
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: September 4, 2012
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • HEREDITARY HEMOCHROMATOSIS GENE
    Publication number: 20110269122
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Application
    Filed: July 7, 2011
    Publication date: November 3, 2011
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Determining genotype of a polymorphic site in the hereditary hemochromatosis gene
    Patent number: 7998680
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: August 16, 2011
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary Hemochromatosis Gene
    Publication number: 20100204051
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 12, 2010
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Polymorphisms in the region of the human hemochromatosis gene
    Patent number: 7595385
    Abstract: Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: September 29, 2009
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David A. Ruddy, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 7579169
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: August 25, 2009
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • METHODS AND COMPOSITIONS RELATED TO A BRAF MUTATION AND MICROSATELLITE STABILITY
    Publication number: 20090181371
    Abstract: Disclosed are methods and compositions related to a BRAF mutation and microsatellite stability.
    Type: Application
    Filed: July 13, 2006
    Publication date: July 16, 2009
    Inventors: Wade S. Samowitz, Martha L. Slattery, Roger K. Wolff
  • Plasmids comprising nucleic acids from the hereditary hemochromatosis gene
    Patent number: 7078513
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: July 18, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 7067255
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: June 27, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Polymorphisms in the region of the human hemochromatosis gene
    Patent number: 7052845
    Abstract: Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: May 30, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David A. Ruddy, Roger K. Wolff
  • Polymorphisms in the region of the human hemochromatosis gene
    Patent number: 7026116
    Abstract: Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: April 11, 2006
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David A. Ruddy, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Publication number: 20030148972
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Application
    Filed: May 2, 2002
    Publication date: August 7, 2003
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Polymorphisms in the region of the human hemochromatosis gene
    Publication number: 20030100747
    Abstract: Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
    Type: Application
    Filed: November 20, 2002
    Publication date: May 29, 2003
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: David A. Ruddy, Roger K. Wolff
  • Method for determining the presence or absence of a hereditary hemochromatosis gene mutation
    Patent number: 6228594
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: May 8, 2001
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene products
    Patent number: 6140305
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: October 31, 2000
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Hereditary hemochromatosis gene
    Patent number: 6025130
    Abstract: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: February 15, 2000
    Assignee: Mercator Genetics, Inc.
    Inventors: Winston J. Thomas, Dennis T. Drayna, John N. Feder, Andreas Gnirke, David Ruddy, Zenta Tsuchihashi, Roger K. Wolff
  • Megabase transcript map: novel sequences and antibodies thereto
    Patent number: 5872237
    Abstract: A fine structure map of the 1 megabase region surrounding the candidate HH gene is provided, along with 250 KB of DNA sequence and 8 loci corresponding to candidate genes within the 1 megabase region. These loci are useful as genetic markers for further mapping studies. Additionally, the eight cDNA sequences corresponding to those loci are useful, for example, for the isolation of other genes in putative gene families, and as probes for diagnostic assays. Additionally, the proteins encoded by those cDNAs are useful in the generation of antibodies for analysis of gene expression and in diagnostic assays, and in the purification of related proteins.
    Type: Grant
    Filed: October 1, 1996
    Date of Patent: February 16, 1999
    Assignee: Mercator Genetics, Inc.
    Inventors: John Nathan Feder, Gregory Scott Kronmal, Peter M. Lauer, David A. Ruddy, Winston Thomas, Zenta Tsuchihashi, Roger K. Wolff
  • Method to diagnose hereditary hemochromatosis
    Patent number: 5753438
    Abstract: New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 19, 1998
    Assignee: Mercator Genetics, Inc.
    Inventors: Dennis T. Drayna, John N. Feder, Andreas Gnirke, Bruce E. Kimmel, Winston J. Thomas, Roger K. Wolff
  • Hereditary hemochromatosis diagnostic markers and diagnostic methods
    Patent number: 5712098
    Abstract: A single base-pair polymorphism involving a mutation from Guanine (G), in individuals unaffected by the hereditary hemochromatosis (HH) gene defect, to Adeninc (A), in individuals affected by the HH gene defect is disclosed. The presence or absence of the polymorphic allele is highly predictive of whether an individual is at risk from HH: the polymorphism is present in 82% of affected individuals and only 4% of a random population screen. Methods of diagnosis, markers, and primers are disclosed and claimed in accordance with the present invention.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: January 27, 1998
    Assignee: Mercator Genetics
    Inventors: Zenta Tsuchihashi, Andreas Gnirke, Winston J. Thomas, Dennis T. Drayna, David Ruddy, Roger K. Wolff, John N. Feder