Patents by Inventor Roger Kei Aoki

Roger Kei Aoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATING PAIN
    Publication number: 20170327810
    Abstract: A single chain polypeptide fusion protein, comprising: a non-cytotoxic protease capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin targeting moiety; a protease cleavage site at which site the fusion protein is cleavable by a protease; a translocation domain capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site; and a second spacer located between the galanin targeting moiety and the translocation domain.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 16, 2017
    Inventors: Peter JAMES, Keith FOSTER, John CHADDOCK, Roger Kei AOKI, Lance STEWARD, Joseph FRANCIS
  • FUSION PROTEINS AND METHODS FOR TREATING, PREVENTING OR AMELIORATIONG PAIN
    Publication number: 20150197739
    Abstract: A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, which protease is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a galanin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease and the galanin Targeting Moiety; a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent; a first spacer located between the non-cytotoxic protease and the protease cleavage site, wherein said first spacer comprises an amino acid sequence of from 4 to 25 amino acid residues; and a second sp
    Type: Application
    Filed: August 27, 2013
    Publication date: July 16, 2015
    Inventors: Peter James, Keith Foster, John Chaddock, Roger Kei Aoki, Lance Steward, Joseph Francis
  • Neuropathic pain treatment method
    Patent number: 7468189
    Abstract: Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: December 23, 2008
    Assignee: Allergan, Inc.
    Inventors: Roger Kei Aoki, Minglei Cui, Stephen W. Jenkins
  • Method for treating allodynia by peripheral administration of a neurotoxin
    Patent number: 7294339
    Abstract: Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: November 13, 2007
    Assignee: Allergan, Inc.
    Inventors: Roger Kei Aoki, Minglei Cui, Stephen W. Jenkins
  • Method for treating hyperalgesia by peripheral administration of a neurotoxin
    Patent number: 7276245
    Abstract: Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: October 2, 2007
    Assignee: Allergan, Inc.
    Inventors: Roger Kei Aoki, Minglei Cui, Stephen W. Jenkins