Abstract: The present invention relates to a system for the computer simulation of a chemical process comprising a plurality of functional modules for completing respective simulation levels of said chemical process, a storage module for storing experimental data relating to chemical species in a data structure that can be used by at least one functional module, a performance evacuation module, in which said process is defined by a set of files shared by ail the modules of the system, each file comprising a description of a raw material and a description of a decomposition of this raw material into chemical species, said files being the inputs and the outputs of said modules of the system, the decomposition into chemical species being preserved throughout the processing operations.

Abstract: A system for computer simulation of a chemical process includes at least a first operation which is described by an explicit algebraic equation. The system includes a receiving module for receiving the first explicit algebraic equation, a processing module which is configured to convert said explicit algebraic equation into an algebraic/differential equation and a resolution module which is configured to solve the algebraic/differential equation.

Abstract: A method for purification of a first polyunsaturated fatty acid from an initial mixture is provided. The initial mixture comprises at least one second fatty acid in addition to the first polyunsaturated fatty acid. The method may comprise separating the first polyunsaturated fatty acid and the second fatty acid in a liquid phase in at least one step of a chromatographic separation process, so as to recover, on the one hand, a stream enriched in the first polyunsaturated fatty acid, and on the other hand, a stream enriched in the second fatty acid. The method may further comprise a step of processing the stream enriched in the first polyunsaturated fatty acid to decrease the peroxide value and/or anisidine value of this stream. The disclosure also provides systems or devices suitably adapted for the implementation of such methods.

Abstract: A method for purification of a first polyunsaturated fatty acid from an initial mixture is provided where the initial mixture comprises at least one second fatty acid in addition to the first polyunsaturated fatty acid. The method may comprise: at least one step of chromatographic separation in liquid phase of the first polyunsaturated fatty acid and the second fatty acid, so as to recover, on the one hand, a stream enriched in the first polyunsaturated fatty acid, and on the other hand, a stream enriched in the second fatty acid; a step of processing the stream enriched in the first polyunsaturated fatty acid, leading to a decrease in the peroxide value and/or anisidine value of this stream. The disclosure also provides a system suitably adapted for the implementation of this method.

Abstract: The invention relates to a chromatography device comprising: a column (12) intended to house, between its two ends (16a, 16b) a chromatographic bed (14) and a fluid to be chromatographed, a fluid layer (48) being defined between a surface of the bed (14) and one (16a) of the ends of the column (12); a piston (36) sliding in the column (12), the piston (36) being one of the ends (16a, 16b) of the column (12); at least a first probe (45, 46) for detecting the surface of the bed (14), the probe (45, 46) being mounted on the end (16a) of the column (12) defining the layer (48); and means (52) for adjusting the position of the piston (36) according to the detection of the surface of the bed (14) by the probe (45, 46). The invention also relates to processes for separating at least two compounds of a fluid to be chromatographed and to methods of adjusting the position of the piston with respect to the surface of the chromatographic bed using the chromatography device.

Abstract: The invention concerns a chromatographic device including a column (12) for receiving a chromatographic bed (14) through which flow a first fluid; a piston (36) sliding inside the column (12) an exerting pressure on the bed (14), a chamber (28) containing a second fluid exerting pressure on the piston (36); a regulator (52) for the pressure exerted by the piston (36) on the bed based on the pressure inside the chamber (28), on the flow pressure on the first fluid at the intake of the column (12) and on a reference pressure of the bed (14). Said device enables to separate at least two compounds to be subjected to chromatographic analysis, while adjusting the pressure exerted on the chromatographic bed. The device efficiently uses the chromatographic bed while protecting it.

Abstract: The invention concerns a method for multiple-column chromatographic spearation producing at least two fractions, comprsing the following steps: in output of the extract, zone 1, or the raffinate zone, zone III: (i) drawing at least part of the output flow of said zone; (ii) concentrationg said part; and (iii) re-injecting at least partly said concentrated part. The invention also concerns a device for implementing said method.

Abstract: A method and device for chromatographic separation producing at least two fractions are provided, in which: (i) the solvent is at least partially evaporated from the fractions produced; (ii) the solvent vapours thus produced are separated; stage (i) of the method being carried out, for at least one of the fractions, at least partially with the separated solvent vapours originating from one of the other evaporated fractions.

Abstract: The invention relates to a chromatography device comprising: a column (12) intended to house, between its two ends (16a, 16b) a chromatographic bed (14) and a fluid to be chromatographed, a fluid layer (48) being defined between a surface of the bed (14) and one (16a) of the ends of the column (12); a piston (36) sliding in the column (12), the piston (36) being one of the ends (16a, 16b) of the column (12); at least a first probe (45, 46) for detecting the surface of the bed (14), the probe (45, 46) being mounted on the end (16a) of the column (12) defining the layer (48); and means (52) for adjusting the position of the piston (36) according to the detection of the surface of the bed (14) by the probe (45, 46). The invention also relates to processes for separating at least two compounds of a fluid to be chromatographed and to methods of adjusting the position of the piston with respect to the surface of the chromatographic bed using the chromatography device.

Abstract: A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable.

Abstract: The invention relates to a chromatography device comprising:

Abstract: A method and device for chromatographic separation producing at least two fractions are provided, in which: (i) the solvent is at least partially evaporated from the fractions produced; (ii) the solvent vapours thus produced are separated; stage (i) of the method being carried out, for at least one of the fractions, at least partially with the separated solvent vapours originating from one of the other evaporated fractions.

Abstract: The invention relates to a process for separating at least one component of a mixture in a simulated moving bed, in which each of the chromatographic columns that contains an adsorbent has a ratio of L (length) to D (diameter) of between 0.01 and 0.34, and the ratio of LTOT (length in n columns) to D (diameter) is between 0.06 and 2.3. It is possible to apply an axial dynamic pressure on each of the upper columns that exceeds the pressure drop of all of the columns.

Abstract: A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable.

Abstract: A method for optimizing the operation of a simulated moving bed (LMS) type (closed or open) separation loop consisting of the interconnection in series of beds containing an adsorbent solid phase, divided into several zones, four for example, delimited by fluid injection and draw-off points (F, El, Ex, R). The optimization sought is obtained by selecting initial values to be imposed on operating variables (internal liquid and solid flows, permutation period, etc.) of a simulated moving bed (LMS) from internal flow rates of a true moving bed (LMV), knowing the flow rate of the feedstock (F) injected in the loop and the concentrations of the various constituents of this feedstock. The invention has an application for optimizing aromatic hydrocarbon or optical isomer separation loops.

Abstract: A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable.

Abstract: The invention concerns a method for separating from a mixture two optical isomers using a simulated moving bed including an assembly of columns divided into at least three successive zones. The amount of charge injected is greater than that of the state of a predetermined reference state. The discharge flow is greater than that of the predetermined reference state if it is required at least to preserve the purity of the less immobilized enantiomer. The discharge flow is less than that of the reference state if it is required to preserve the purity of the more immobilized enantiomer.

Abstract: A process for separating at least one component of a mixture in a set of closed-loop chromatographic columns is described, whereby the loop comprises at least one feedstock injection point, a raffinate draw-off point, an eluant injection point, and an extract draw-off point, in which a determination is made between an injection point and a draw-off point or vice-versa a chromatographic zone, and at the end of a given period of time, all of the injection points and draw-off points are shifted by the same number of columns or column sections and advantageously by one column or column section in a given direction that is defined relative to that of the flow of a main fluid that circulates through the loop. During the period, the shifting of different injection points and draw-off points of at least one column or column section is done at different times in such a way that the lengths of the zones that are defined by said different points are variable.

Abstract: Method for optimizing the operation of a simulated moving bed (LMS) type (closed or open) separation loop consisting of the interconnection in series of beds containing an adsorbent solid phase, divided into several zones, four for example, delimited by fluid injection and draw-off points (F, El, Ex, R).

Abstract: The invention relates to a process and a device for separating at least one component of a mixture in a simulated moving bed, in which each of the chromatographic columns that contains an absorbent has a ratio of L (length) to D (diameter) of between 0.01 and 0.34.