Abstract: Sodium sulfide hydrate is at least partially dehydrated by heating with N-methyl 2-pyrrolidone. 2-Chlorobenzamide is added to the mixture which is heated further. The mixture is cooled and treated with aqueous hydrogen peroxide to give the sodium salt of 1,2-benzisothiazolin-3-one in good yield. Acidification if desired gives rise to the free 1,2-benzisothiazolin-3-one.

Abstract: A method of estimating fluid composition in an earth formation includes: generating at least one pulsed neutron measurement by a pulsed neutron tool; estimating a pulsed neutron fluid saturation by analyzing the at least one pulsed neutron measurement via a pulsed neutron model of the earth formation, the pulsed neutron model including expected pulsed neutron measurements relative to selected fluid composition and properties; comparing the pulsed neutron fluid saturation to a reference fluid saturation estimated via a downhole tool; adjusting the pulsed neutron model to at least substantially eliminate a difference between the pulsed neutron fluid saturation and the reference fluid saturation by adjusting at least one of the selected fluid composition and the selected fluid properties; and estimating at least one of the fluid composition and the fluid properties based on the adjusted model.

Abstract: N-alkylated 1,2-benzisothiazolin-3-ones can be prepared in good yield and good selectivity by reaction of the lithium salt of 1,2-benzisothiazolin-3-one with an electrophilic alkylating agent.

Abstract: Sodium sulfide hydrate is at least partially dehydrated by heating with N-methyl 2-pyrrolidone. 2-Chlorobenzamide is added to the mixture which is heated further. The mixture is cooled and treated with aqueous hydrogen peroxide to give the sodium salt of 1,2-benzisothiazolin-3-one in good yield. Acidification if desired gives rise to the free 1,2-benzisothiazolin-3-one.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes. These compounds are inhibitors of Nav1.7.

Abstract: A method of estimating fluid composition in an earth formation includes: generating at least one pulsed neutron measurement by a pulsed neutron tool; estimating a pulsed neutron fluid saturation by analyzing the at least one pulsed neutron measurement via a pulsed neutron model of the earth formation, the pulsed neutron model including expected pulsed neutron measurements relative to selected fluid composition and properties; comparing the pulsed neutron fluid saturation to a reference fluid saturation estimated via a downhole tool; adjusting the pulsed neutron model to at least substantially eliminate a difference between the pulsed neutron fluid saturation and the reference fluid saturation by adjusting at least one of the selected fluid composition and the selected fluid properties; and estimating at least one of the fluid composition and the fluid properties based on the adjusted model.

Abstract: This invention relates to compounds of formula (I)

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Abstract: This invention relates to compounds of formula (I)

Abstract: This invention relates to compounds of formula (I)

Abstract: This invention relates to compounds of formula (I).

Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii) one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; and R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treati

Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents H, C1-6-alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R2 represents H, C1-6alkyl (optionally substituted by R3), phenyl (optionally substituted by CN), or Het; R3 represents OH, CN, Het, —R4—C1-6alkyl, or CONR5R6; R4 represents —CO2—, or —O—; R5 and R6 independently represent H, C1-6alkyl (optionally substituted by OR7) or C3-8cycloalkyl; R7 represents H or C1-6alkyl; Het represents a five or six membered aromatic heterocyclic group containing (i) from one to four nitrogen heteroatom(s) or (ii) one or two nitrogen heteroatom(s) and one oxygen or one sulphur heteroatom or (iii)one or two oxygen or sulphur heteroatom(s), said heterocyclic group being optionally substituted by one or more groups selected from CN and C1-6alkyl; R8 represents C1-6alkyl, C1-6alkyloxy, C3-8cycloalkyl, or halo; R9 and R10 independently represent H, C1-6alkyl, C1-6alkyloxy, CN, CF3 or halo; may be useful for treating e

Abstract: This invention relates to compounds of formula (I).

Abstract: An improved, high strength construction system that uses post tensioning. It is comprised of a series of interconnected, super heavy duty hollow core blocks 102 with minimal ducts 103, a series of tendons 105, and a plurality of anchors or plates 104 with additional features. The system 101 is configured with the plurality of adjacent blocks 102 contiguous and touching one another and demountably coupled to each other by means of the tendons 105 and anchors 103. The unique features include a strong, durable full plate 104 and bolt 105 both of which may be treated for corrosion resistance. This new coupling results in a structure that is far stronger than an ordinary block structure built with mortar and standard reinforcing. The SYSTEM has more predictable and controlled strength which is stronger than most reinforced concrete systems.

Abstract: The present invention comprises a class of 5,7-diaminopyrazolo[4,3-d]pyrimidine compounds. These compounds are useful as phosphodiesterase type 5 inhibitors. The present invention further comprises compositions containing the compounds use of the compounds and compositions to treat hypertension and other conditions, processes for the preparation of the compounds, and intermediates used in the preparation of the compounds.

Abstract: An improved mortar less masonry structure comprising a plurality of concrete masonry units connected to each other by metal bars and metal threaded fasteners thereby forming a reinforcing skeletal system for a post tensioned structure. The improved system has been developed for use in constructing various types of masonry structures. The improvements of the system feature masonry units with recessed channels, pocket channels, or fully embedded bars as anchors. The bolt acts as the tendon for the post tensioning system which traverse the hollow cavities as ducts. Other new features teach a strong and durable full plate anchor and high strength tendons for defensive and anti-terrorism structures. This is an improved building system that demountably couples each individual masonry unit by a bar and bolt system. This coupling results in stronger, faster, and cheaper construction of masonry structures.

Abstract: A mortar less masonry structure comprising a plurality of regular masonry blocks and/or bricks connected to each other by a plurality of metal bars and a plurality of standard metal threaded fasteners thereby forming a post tensioned structure. Preferably, the blocks are operatively connected to each other as a structure by simple mechanical tools. Each interconnection results in a unitized post tensioned member that, when interconnected to the adjacent members, forms a comparatively higher strength structure than systems made of mortar and reinforced mortar. The method used to create this structure is a simple, waterless, mortar less interconnection process that is completed by a series of simple individual steps of fastening the blocks and bars into a strong and durable structure. Once connected the structure is strong and durable. If desired, the structure may be disassembled and the components be re-used.