Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises making a plurality of folds in a first direction in a sheet of paper; making a plurality of folds in a second direction perpendicular to said first direction to form folded articles; making a fold in said second direction to form an outsert; and applying pressure to at least one of said folded articles or said outsert, said pressure being at least about 30 pounds per square inch, said pressure being applied by a pressing unit comprising a plurality of pressure rollers.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises applying a plurality of parallel lines of water to a sheet of paper; making a plurality of folds in the sheet of paper in a direction parallel to a first direction with a first folding apparatus to form a first folded article; making a plurality of folds in the first folded article in a second direction perpendicular to the first direction to form an intermediate folded article; and making a final fold in the intermediate folded article in the second direction to form the outsert. Making the final fold may include forcing the intermediate folded article between a pair of adjustably-spaced folding members, the adjustably-spaced folding members to be adjustably spaced apart from each other by a distance that is within a range defined by a lower boundary of 0.25 inches and an upper boundary of 0.45 inches.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises applying a plurality of parallel lines of water to a sheet of paper using a plurality of spray nozzles and being applied at positions at which folds are to be made; making a plurality of folds in a first direction in the sheet of paper with a first folding apparatus; making a plurality of folds in a second direction perpendicular to the first direction; and making a fold in in the second direction to form an outsert including causing a movable member of a folding apparatus to make contact with and move a folded article towards a folding roller, and so that the folded article makes contact with the folding roller to form a fold in the folded article.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises making a plurality of folds in a first direction in a sheet of paper; aking a plurality of folds in a second direction perpendicular to said first direction to form folded articles; making another fold in said second direction to form an outsert including causing a movable member of a folding apparatus to make contact with and move an intermediate portion of a folded article towards a pair of adjustably-spaced folding members, at least one of said adjustably-spaced folding members having a position that is adjustable to allow said adjustably-spaced folding members to be adjustably spaced apart from each other by a distance that is within a range defined by a lower boundary of 0.25 inches and an upper boundary of 0.45 inches.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include (a) folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a plurality of folds in the first folded article in a second direction perpendicular to the first direction; and (c) making a final fold in the second direction to form an outsert using a folding apparatus having a pair of adjustably-spaced folding rollers having a nip therebetween and a movable blade member, with the folding rollers spaced apart by a distance within a range of 0.25 inches and 0.45 inches. Water scoring may be used to facilitate folding of the sheet of paper.

Abstract: Outserts having printed information thereon are disclosed and are formed in accordance with a method in which a plurality of parallel folds are made in a sheet of paper in a first fold direction using a plurality of pairs of folding rollers and stop members to form an intermediate folded item and in which a plurality of cross-folds are made in the intermediate folded item to form the outsert. The cross-folds may be made to divide the length of the intermediate folded item into ten panels, fourteen panels, or eighteen panels.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include (a) folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a plurality of folds in the first folded article in a second direction perpendicular to the first direction; and (c) making a final fold in the second direction to form an outsert using a folding apparatus having a pair of adjustably-spaced folding rollers having a nip therebetween and a movable blade member, with the folding rollers spaced apart by a distance within a range of 0.25 inches and 0.45 inches. Water scoring may be used to facilitate folding of the sheet of paper.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article a first pressing unit having a pair of pressure rollers; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises making a plurality of folds in a first direction in a sheet of paper; aking a plurality of folds in a second direction perpendicular to said first direction to form folded articles; making another fold in said second direction to form an outsert including causing a movable member of a folding apparatus to make contact with and move an intermediate portion of a folded article towards a pair of adjustably-spaced folding members, at least one of said adjustably-spaced folding members having a position that is adjustable to allow said adjustably-spaced folding members to be adjustably spaced apart from each other by a distance that is within a range defined by a lower boundary of 0.25 inches and an upper boundary of 0.45 inches.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises applying a plurality of parallel lines of water to a sheet of paper; making a plurality of folds in the sheet of paper in a direction parallel to a first direction with a first folding apparatus to form a first folded article; making a plurality of folds in the first folded article in a second direction perpendicular to the first direction to form an intermediate folded article; and making a final fold in the intermediate folded article in the second direction to form the outsert. Making the final fold may include forcing the intermediate folded article between a pair of adjustably-spaced folding members, the adjustably-spaced folding members to be adjustably spaced apart from each other by a distance that is within a range defined by a lower boundary of 0.25 inches and an upper boundary of 0.45 inches.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises making a plurality of folds in a first direction in a sheet of paper; making a plurality of folds in a second direction perpendicular to said first direction to form folded articles; making a fold in said second direction to form an outsert; and applying pressure to at least one of said folded articles or said outsert, said pressure being at least about 30 pounds per square inch, said pressure being applied by a pressing unit comprising a plurality of pressure rollers.

Abstract: A method of using a folding apparatus to form an outsert having product information printed thereon comprises applying a plurality of parallel lines of water to a sheet of paper using a plurality of spray nozzles and being applied at positions at which folds are to be made; making a plurality of folds in a first direction in the sheet of paper with a first folding apparatus; making a plurality of folds in a second direction perpendicular to the first direction; and making a fold in in the second direction to form an outsert including causing a movable member of a folding apparatus to make contact with and move a folded article towards a folding roller, and so that the folded article makes contact with the folding roller to form a fold in the folded article.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: Outserts having printed information thereon are disclosed and are formed in accordance with a method in which a plurality of parallel folds are made in a sheet of paper in a first fold direction using a plurality of pairs of folding rollers and stop members to form an intermediate folded item and in which a plurality of cross-folds are made in the intermediate folded item to form the outsert. The cross-folds may be made to divide the length of the intermediate folded item into ten panels, fourteen panels, or eighteen panels.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article a first pressing unit having a pair of pressure rollers; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: A method of forming a composite informational item having information regarding a pharmaceutical product printed thereon from a first informational item, such as a bidirectionally folded outsert or a booklet, and a second informational item, such as a bidirectionally folded outsert or a booklet, may comprise (a) forming the first informational item; (b) automatically conveying the first informational item from a location in a first feed apparatus to a bonding location; (c) providing a plurality of the second informational items in a second feed apparatus different than the first feed apparatus; (d) automatically depositing a releasable adhesive on a face of one of the informational items; (e) automatically conveying one of the second informational items from a location in the second feed apparatus to the bonding location; and (f) causing a face of the first informational item to make contact with a face of the second informational item so that the first informational item and the one second informational item

Abstract: A method and apparatus for forming informational items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article; (b) making a fold in the first folded article to form a second folded article; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article a first pressing unit having a pair of pressure rollers; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member.

Abstract: A method and apparatus for forming informationbal items such as outserts and booklets may include folding a sheet of paper having product information printed thereon by making a plurality of folds in the sheet of paper to form a first folded article, the folds in the sheet of paper being made using a first folding apparatus having a plurality of folding rollers; (b) making a fold in the first folded article to form a second folded article, the fold being parallel to a second direction perpendicular to the first direction, the fold being made using a second folding apparatus having a plurality of folding rollers; (c) applying pressure at least about 30 psi and no greater than about 500 psi to the second folded article a first pressing unit having a pair of pressure rollers; and (d) making one or more folds in the second folded article to form an outsert using a third folding apparatus having a plurality of folding rollers having a nip therebetween and a movable blade member, the movable blade member making con

Abstract: Outserts having printed information thereon are disclosed and are formed in accordance with a method in which a plurality of parallel folds are made in a sheet of paper in a first fold direction using a plurality of pairs of folding rollers and stop members to form an intermediate folded item and in which a plurality of cross-folds are made in the intermediate folded item to form the outsert. The cross-folds may be made to divide the length of the intermediate folded item into ten panels, fourteen panels, or eighteen panels.