Patents by Inventor Roger Michael Hendry

Roger Michael Hendry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
    Patent number: 8647638
    Abstract: The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV), More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: February 11, 2014
    Assignee: Wyeth LLC
    Inventors: David Kirkwood Clarke, Roger Michael Hendry, Stephen A. Udem, Christopher Lee Parks
  • Synergistic Attenuation of Vesicular Stomatitis Virus, Vectors Thereof and Immunogenic Compositions Thereof
    Publication number: 20130023032
    Abstract: The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV), More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.
    Type: Application
    Filed: August 31, 2012
    Publication date: January 24, 2013
    Applicant: Wyeth LLC
    Inventors: David Kirkwood Clarke, Roger Michael Hendry, Stephen A. Udem, Christopher Lee Parks
  • Synergistic attenuation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof
    Patent number: 8287878
    Abstract: The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV). More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: October 16, 2012
    Assignee: Wyeth LLC
    Inventors: David Kirkwood Clarke, Roger Michael Hendry, Stephen A. Udem, Christopher Lee Parks
  • Genetically Modified Attenuated Vesicular Stomatitis Virus, Compositions and Methods of use Thereof
    Publication number: 20090175906
    Abstract: The present invention relates to methods for generating genetically modified and attenuated strains of vesicular stomatitis virus (VSV) for use in the preparation of immunogenic compositions. More particularly, the invention relates to the identification of particular genetic modifications of attenuated VSV that result in an increased yield of virus and an increase in stability of the attenuated strains for preparation of the immunogenic compositions. Methods for cell culture propagation and use in large scale production of VSV is also disclosed.
    Type: Application
    Filed: December 18, 2008
    Publication date: July 9, 2009
    Applicant: Wyeth
    Inventors: Narender Kumar Kalyan, Irina Yurgelonis, Roger Michael Hendry, Mark William Cutler, Kristen Elissa Syvertsen
  • METHODS FOR PACKAGING PROPAGATION-DEFECTIVE VESICULAR STOMATITIS VIRUS VECTORS
    Publication number: 20090175900
    Abstract: A method of producing propagation-defective Vesicular Stomatitis Virus (VSV) in a cell culture is provided. The method involves introducing a plasmid vector encoding an optimized VSV G gene into a cell; expressing VSV G protein from the optimized VSV G gene; and introducing a propagation-defective VSV into the cell expressing the VSV G protein encoded by the optimized VSV G gene. The method further includes growing the cells in culture; and recovering the propagation-defective VSV from the culture.
    Type: Application
    Filed: December 16, 2008
    Publication date: July 9, 2009
    Applicant: Wyeth
    Inventors: Christopher L. Parks, Susan E. Witko, Maninder K. Sidhu, J. Erik Johnson, Roger Michael Hendry
  • METHODS FOR PACKAGING PROPAGATION-DEFECTIVE VESICULAR STOMATITIS VIRUS VECTORS USING A STABLE CELL LINE THAT EXPRESSES G PROTEIN
    Publication number: 20090162321
    Abstract: A method of producing propagation-defective Vesicular Stomatitis Virus (VSV) is provided. The method involves providing a cell that includes an optimized VSV G gene, wherein expression of VSV G protein from the optimized VSV G gene is inducible; and inducing the cell to express VSV G protein from the optimized VSV G gene. The method also involves infecting the induced cell with an attenuated VSV; growing the infected cells in culture; and recovering attenuated VSV from the culture.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 25, 2009
    Applicant: Wyeth
    Inventors: Christopher L. Parks, Susan E. Witko, Maninder K. Sidhu, J. Erik Johnson, Roger Michael Hendry