Patents by Inventor Roger N. Farr

Roger N. Farr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of gonadotropin releasing hormone antagonists
    Patent number: 6620824
    Abstract: The present invention relates to a process for preparing a compound of gonadotropin releasing hormone antagonists having a Formula I, in an efficient way, which involves preparation of key intermediates: 2-arylindole core; a chiral aziridine, in particular chiral nosyl aziridine; and an amine salt. The key process involves the coupling reaction of 2-arylindole and nosyl aziridine under boron trifluoride catalysis, which provides the final compound with unprecedented regioselectivity and enantioselectivity.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: September 16, 2003
    Assignee: Merck & Co., Inc.
    Inventors: John Y. L. Chung, Roger N. Farr, Guy R. Humphrey
  • Process for the synthesis of gonadotropin releasing hormone antagonists
    Publication number: 20030013876
    Abstract: The present invention relates to a process for preparing a compound of gonadotropin releasing hormone antagonists having a Formula I, 1
    Type: Application
    Filed: April 5, 2002
    Publication date: January 16, 2003
    Inventors: John Y. L. Chung, Roger N. Farr, Guy R. Humphrey
  • Intermediates for making heterocycles useful as COX-2 inhibitors
    Patent number: 6153787
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: November 28, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Guo-Jie Ho, Ralph P. Volante, Roger N. Farr, David J. Mathre
  • 3-substitutes isoxazolidines as chiral auxiliary agents
    Patent number: 6020497
    Abstract: Disclosed are compounds of the formula: ##STR1## where R is selected from the group consisting of C.sub.1 -C.sub.4 linear or branched alkyl, trifluoromethyl, halo, phenyl, biphenyl and naphthyl, wherein the aromatic group can be substituted with C.sub.1 -C.sub.4 linear or branched alkyl, trifluoromethyl, or halo; and wherein the asterisked 3-position ring carbon is either in (R) or (S) configuration, or racemate form, and salts thereof formula I. The compounds are useful in chiral synthesis, for example, producing naturally occurring L-amino acids, e.g., alanine, from aliphatic acid precursors.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: February 1, 2000
    Assignee: Merck & Co., Inc.
    Inventor: Roger N. Farr
  • Process for making phenyl heterocycles useful as cox-2 inhibitors
    Patent number: 5883267
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Ralph P. Volante, Guo-Jie Ho, Roger N. Farr, David J. Mathre