Patents by Inventor Roger Nani
Roger Nani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230391799Abstract: Aspects of the application provide compounds of formula (I): or a salt thereof, which may be useful as chromophores and/or fluorophores for labeling highly water-soluble biomolecules (e.g., proteins, polypeptides, nucleotides, or oligonucleotides).Type: ApplicationFiled: May 2, 2023Publication date: December 7, 2023Applicant: Quantum-Si IncorporatedInventors: Roger Nani, Haidong Huang
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Publication number: 20230192761Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.Type: ApplicationFiled: June 10, 2022Publication date: June 22, 2023Applicant: Quantum-Si IncorporatedInventors: Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Patent number: 11358981Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.Type: GrantFiled: January 20, 2021Date of Patent: June 14, 2022Assignee: Quantum-Si IncorporatedInventors: Haidong Huang, Roger Nani, Omer Ad, Robert E. Boer
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Publication number: 20210379591Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).Type: ApplicationFiled: April 21, 2021Publication date: December 9, 2021Applicant: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Publication number: 20210354134Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).Type: ApplicationFiled: April 21, 2021Publication date: November 18, 2021Applicant: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Publication number: 20210354133Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).Type: ApplicationFiled: April 21, 2021Publication date: November 18, 2021Applicant: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Publication number: 20210331170Abstract: Methods and devices for preparing target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices involve sample lysis, sample fragmentation, enrichment of target molecule(s), and/or functionalization of target molecule(s).Type: ApplicationFiled: April 21, 2021Publication date: October 28, 2021Applicant: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Publication number: 20210221839Abstract: The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.Type: ApplicationFiled: January 20, 2021Publication date: July 22, 2021Applicant: Quantum-Si IncorporatedInventors: Haidong Huang, Roger Nani, Omer Ad, Brian Reed, Matthew Dyer, Robert E. Boer
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Publication number: 20200219590Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: November 15, 2019Publication date: July 9, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209249Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209255Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209253Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209257Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209256Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200209254Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.Type: ApplicationFiled: December 10, 2019Publication date: July 2, 2020Applicant: Quantum-Si IncorporatedInventors: Brian Reed, Jeremy Lackey, Thomas Christian, Roger Nani, David Dodd, Kathren Croce, Alexander Goryaynov, Jonathan M. Rothberg
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Publication number: 20200031861Abstract: Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.Type: ApplicationFiled: July 12, 2019Publication date: January 30, 2020Applicant: Quantum-Si IncorporatedInventors: Jonathan M. Rothberg, Jeremy Lackey, Roger Nani, David Dodd
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Patent number: 9541558Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.Type: GrantFiled: September 4, 2013Date of Patent: January 10, 2017Assignee: California Institute of TechnologyInventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman
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Publication number: 20140072981Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.Type: ApplicationFiled: September 4, 2013Publication date: March 13, 2014Applicant: California Institute of TechnologyInventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman
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Patent number: 8541593Abstract: The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.Type: GrantFiled: June 20, 2008Date of Patent: September 24, 2013Assignee: Amgen Inc.Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret M. Faul, Roger Nani, Jay Larrow
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Publication number: 20100280255Abstract: The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.Type: ApplicationFiled: June 20, 2008Publication date: November 4, 2010Applicant: AMGEN INC.Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret Faul, Roger Nani, Jay Larrow
