Abstract: A combustor panel is disclosed herein. The combustor panel includes a top side, a bottom side opposite the top side, a feature coupled to the top side and extending orthogonally away from the top side, the feature defining a first space on the bottom side beneath the feature, a first plurality of cooling holes extending in a first direction from the top side to the bottom side, a second plurality of cooling holes extending in a second direction from the top side to the bottom side, the second direction being rotated about 1° to about 60° counter-clockwise from the first direction, and a third plurality of cooling holes extending in a third direction from the top side to the bottom side, the third direction being about rotated 1° to about 60° clockwise from the first direction.

Abstract: A combustor panel is disclosed herein. The combustor panel includes a top side, a bottom side opposite the top side, a feature coupled to the top side and extending orthogonally away from the top side, the feature defining a first space on the bottom side beneath the feature, a first plurality of cooling holes extending in a first direction from the top side to the bottom side, a second plurality of cooling holes extending in a second direction from the top side to the bottom side, the second direction being rotated about 1° to about 60° counter-clockwise from the first direction, and a third plurality of cooling holes extending in a third direction from the top side to the bottom side, the third direction being about rotated 1° to about 60° clockwise from the first direction.

Abstract: The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.

Abstract: A combustor panel arrangement for a gas turbine engine. The combustor panel arrangement includes a first combustor panel that has a first edge. A second combustor panel has a second edge facing the first edge. A first plurality of effusion holes extend through the first edge towards the second edge along a corresponding one of a first plurality of flow paths. A second plurality of effusion holes extend through the second edge along a corresponding one of a second plurality flow paths towards the first edge. The first plurality of flow paths and the second plurality of flow paths are non-intersecting.

Abstract: A shrouded conduit is provided for arranging, for example, in a gas path of a turbine engine. The shrouded conduit includes a tubular shroud extending longitudinally along a centerline. The shrouded conduit also includes a fluid conduit extending longitudinally in the shroud. A first portion of the fluid conduit is connected laterally to and may be formed integral with a first portion of the shroud.

Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Abstract: An additively manufactured component includes a heat transfer augmentation feature with a surface finish between about 125-900 micro inches.

Abstract: A method is provided involving an additive manufacturing system. This method includes a step of forming a first fluid conduit using the additive manufacturing system. The method also includes a step of providing a fluid coupling. The fluid coupling includes the first fluid conduit and a second fluid conduit. The first fluid conduit is connected to and fluidly coupled with the second fluid conduit. The first fluid conduit has a first configuration. The second fluid conduit has a second configuration that is different than the first configuration.

Abstract: The present invention relates to compounds and their use as ligands for mu opioid receptors. Also included are methods for preparing the compounds and pharmaceutical compositions containing the compounds. In one or more embodiments of the invention, a compound according to Formula I is provided: and pharmaceutically acceptable salts thereof, wherein R1-R11 are as described herein.

Abstract: A combustor panel arrangement for a gas turbine engine. The combustor panel arrangement includes a first combustor panel that has a first edge. A second combustor panel has a second edge facing the first edge. A first plurality of effusion holes extend through the first edge towards the second edge along a corresponding one of a first plurality of flow paths. A second plurality of effusion holes extend through the second edge along a corresponding one of a second plurality flow paths towards the first edge. The first plurality of flow paths and the second plurality of flow paths are non-intersecting.

Abstract: A fuel injector is provided for a gas turbine engine. The fuel injector includes a fuel conduit and a cooling fluid circuit through a strut. A gas turbine engine is provided that includes a multiple of fuel injectors in communication with a combustor and a cooling system in communication with each of the multiple of fuel injectors.

Abstract: A method is provided involving an additive manufacturing system. This method includes a step of forming a first fluid conduit using the additive manufacturing system. The method also includes a step of providing a fluid coupling. The fluid coupling includes the first fluid conduit and a second fluid conduit. The first fluid conduit is connected to and fluidly coupled with the second fluid conduit. The first fluid conduit has a first configuration. The second fluid conduit has a second configuration that is different than the first configuration.

Abstract: A flowpath assembly has a first conduit defining a flowpath radially inward, and a second conduit spaced radially outward from the first conduit. A void defined between the first and second conduits contains an insulating material that may have a greater porosity than the first and second conduits. The assembly may be additive manufactured generally as one unitary piece with the raw material of the conduits being melted and solidified on a slice-by-slice basis and the insulating material being selectively bypassed by an energy gun of an additive manufacturing system.

Abstract: A welding apparatus having a welding tool and a weld cooling apparatus for forced cooling of the weld zone. The welding tool has a welding nozzle with a longitudinal axis, and the weld cooling apparatus uses a source of CO2 as the coolant. A coolant delivery conduit is arranged to move with the welding tool and has a first tube with a longitudinal axis that extends alongside the welding tool, and a second tube with a longitudinal axis extending downwardly and away from the welding tool. A coolant nozzle is located at the end of the second tube to eject coolant at the weld zone. The coolant nozzle outlet is spaced from the workpiece and arranged to direct a jet of coolant behind the welding tool onto the weld zone at least 10 mm from the longitudinal axis of the first tube.

Abstract: One embodiment includes a fuel injector. The fuel injector assembly comprises a conduit for conveying fuel from a fuel inlet to a nozzle. The conduit is located in a support, with the conduit, the nozzle, and the support being a single unitary piece. A thermally compliant feature is located at the nozzle which allows the fuel injector to adjust for differential thermal expansion.

Abstract: A tube assembly that may be for a fuel nozzle of a fuel system of a gas turbine engine may have a first tube defining a first flowpath along a centerline, a second tube generally spaced radially outward from the first tube with a first void located between and defined by the first and second tubes, and a support structure located in the first void and extending between the first and second tubes. The support structure is constructed and arranged to minimize or eliminate thermal conduction between the tubes. The entire assembly may be additive manufactured as one unitary piece. One example of a method of operation may include designed-for breakage of the structural support due to thermal stresses thereby further minimizing thermal conduction between tubes.

Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Abstract: A fluid dispensing apparatus that may be additive manufactured as one unitary piece and may be a fuel injector for a gas turbine engine includes a radial displacement bellows having an outer surface that faces and may be exposed to a surrounding environment and an interior surface that faces and may define at least in-part a flowpath extending along a centerline. The radial displacement bellows is constructed and arranged to move between an expanded state when a pressure differential between the environment and the flowpath is low to a restricted state when the pressure differential is high.

Abstract: The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Abstract: A tube assembly that may be for a fuel nozzle of a fuel system of a gas turbine engine may have a first tube defining a first flowpath along a centerline, a second tube generally spaced radially outward from the first tube with a first void located between and defined by the first and second tubes, and a support structure located in the first void and extending between the first and second tubes. The support structure is constructed and arranged to minimize or eliminate thermal conduction between the tubes. The entire assembly may be additive manufactured as one unitary piece. One example of a method of operation may include designed-for breakage of the structural support due to thermal stresses thereby further minimizing thermal conduction between tubes.