Patents by Inventor Roger O'Neill
Roger O'Neill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9400277Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: GrantFiled: November 19, 2010Date of Patent: July 26, 2016Assignee: ProteinSimpleInventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
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Patent number: 9304133Abstract: Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.Type: GrantFiled: April 22, 2011Date of Patent: April 5, 2016Assignee: ProteinSimpleInventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
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Patent number: 8940232Abstract: An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run: Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.Type: GrantFiled: February 27, 2013Date of Patent: January 27, 2015Assignee: ProteinSimpleInventors: David J. Roach, Tom W. Yang, Roger A. O'Neill, Robert T. Loder, Jr.
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Publication number: 20140106372Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: September 27, 2013Publication date: April 17, 2014Applicant: PROTEINSIMPLEInventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
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Publication number: 20120213667Abstract: An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run. Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.Type: ApplicationFiled: September 19, 2011Publication date: August 23, 2012Applicant: ProteinSimpleInventors: David J. Roach, Tom W. Yang, Roger A. O'Neill, Robert T. Loder, JR., Peter B. Vander Horn
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Patent number: 8021611Abstract: An automated assay system is described with stations for placement of materials to be used in an assay of materials inside capillaries and an automated gripper for manipulating capillaries. The system includes a separation and immobilization station where reactions inside the capillaries take place and a detector station where photoemissions from the capillary reactions are detected. The photoemissions from the capillaries may be displayed as line graphs or in columns of a pseudo-gel image resembling the familiar Western gel blot. An automated control system has a user interface by which an operator can select a run protocol and define the locations of samples and reagents to be used in the protocol run. Following the setup the control system will cause the automated system to execute the protocol, then display the results in a selected display format.Type: GrantFiled: April 10, 2006Date of Patent: September 20, 2011Assignee: ProteinSimpleInventors: David J. Roach, Tom W. Yang, Roger A. O'Neill, Robert T. Loder, Jr., Peter B. Vander Horn
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Publication number: 20110195527Abstract: Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.Type: ApplicationFiled: April 22, 2011Publication date: August 11, 2011Applicant: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
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Publication number: 20110132761Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: November 19, 2010Publication date: June 9, 2011Applicant: Cell Biosciences, Inc.Inventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
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Patent number: 7935489Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: GrantFiled: July 19, 2005Date of Patent: May 3, 2011Assignee: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom Weisan Yang
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Patent number: 7935308Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: GrantFiled: October 30, 2007Date of Patent: May 3, 2011Assignee: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom Weisan Yang
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Patent number: 7935479Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are described herein. In some embodiments a method includes resolving one or more analytes in a fluid path, such as, for example, a capillary. After the one or more analytes are resolved, the one or more analytes are bound to the fluid path upon activation of one or more triggerable agents disposed within the fluid path. The one or more analytes that are bound to the fluid path are detected within the fluid path.Type: GrantFiled: March 19, 2007Date of Patent: May 3, 2011Assignee: Cell Biosciences, Inc.Inventors: Roger A. O'Neill, Marc Glazer, Tom W. Yang, Daniel J. Suich, Karl O. Voss
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Patent number: 7846676Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: GrantFiled: October 30, 2007Date of Patent: December 7, 2010Assignee: Cell Biosciences, Inc.Inventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
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Publication number: 20090023225Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: October 30, 2007Publication date: January 22, 2009Inventors: Tom Weisan Yang, Arunashree Bhamidipati, Andrei V. Bordunov, James Eugene Knittle, Roger A. O'Neill, Karl O. Voss
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Publication number: 20080254552Abstract: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.Type: ApplicationFiled: October 30, 2007Publication date: October 16, 2008Inventors: Roger A. O'Neill, Marc Glazer, Tom Weisan Yang
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Publication number: 20080017512Abstract: In general, the present invention provides microfluidic devices comprised of polymer coatings with triggerable analyte capture moieties. In some embodiments, a microfluidic device is provided, useful in electrophoresis, and is comprised of at least one separation channel with a surface, such as but not necessarily an inner surface, and having a polymer coating introduced onto the surface. The polymer coating is comprised of moieties capable of being triggered to immobilize analytes to the surface.Type: ApplicationFiled: January 16, 2007Publication date: January 24, 2008Inventors: Andrei V. Bordunov, Karl O. Voss, Lane A. Clizbe, Roger A. O'Neill
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Patent number: 7320775Abstract: There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.Type: GrantFiled: May 14, 2002Date of Patent: January 22, 2008Assignee: Guava Technologies, Inc.Inventors: Thomas E. Kochy, Roger A. O'Neill, Terah W. Smiley, Vidal O. Smith
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Publication number: 20080009078Abstract: Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to the wall of the fluid path. Attachment results from a triggerable event such as photoactivation, thermal activation, or chemical activation. In accordance with a further aspect of the present invention, the material in the capillary may also be disrupted, by either the triggerable event or a subsequent event such as melting or photocleavage. Thus, an open lumen or porous structure may be created within the fluid path, allowing unbound analyte materials to be washed from the fluid path, and detection agents to be washed into the fluid path. The separation-compatible materials may be polymerizable monomers, gels, entangled polymers or other materials.Type: ApplicationFiled: March 19, 2007Publication date: January 10, 2008Inventors: Roger O'Neill, Marc Glazer, Tom Yang, Daniel Suich, Karl Voss
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Publication number: 20060292649Abstract: Automated protein assay apparatus and methods suitable for use in a reference lab are described. A screening test for a pathogen or disease condition is performed at the reference lab. If the results of the screening test are positive, a definitive assay is performed. One or more analytes are resolved in a fluid path such as that of a capillary by isoelectric focusing. The resolved analytes are immobilized in the capillary by photoimmobilization. A typical analyte is a protein of a biological sample of a subject. Detection agents such as antibodies are flowed through the capillary which bind to or interact with the analytes, forming antibody-protein complexes. A chemiluminescent substrate is flowed through the capillary and detected with a photon detector. The detected locations of the analytes are recorded and the results sent to the referring physician.Type: ApplicationFiled: May 9, 2006Publication date: December 28, 2006Inventors: Linda Cahill, Roger O'Neill
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Publication number: 20060292558Abstract: Automated protein assay apparatus and methods for measuring antibodies against an analyte are described. A standard mixture of one or more analytes is loaded into a capillary, the analytes are resolved by isoelectric focusing and immobilized in the capillary. Serum from a human or non-human subject under analysis is flowed through the capillary and antibodies specific for the immobilized analytes bind to the analytes. A secondary antibody including a detectable marker is introduced, binding to the immobilized antibody-analyte complexes. The locations of the antibody-analyte complexes are detected by means of the detectable markers, revealing the presence of analyte-specific antibodies in the serum.Type: ApplicationFiled: May 9, 2006Publication date: December 28, 2006Inventor: Roger O'Neill
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Publication number: 20060257917Abstract: Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays.Type: ApplicationFiled: August 1, 2006Publication date: November 16, 2006Inventors: Roger O'Neill, Peter Fisher