Abstract: The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.

Abstract: Heterocyclic thromboxane synthetase inhibitors of the formula ##STR1## wherein R.sup.1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, hydroxy or C.sub.1 -C.sub.4 alkoxy;Y, which is attached to the 2- or 3-position, is --COOH, --COO(C.sub.1 -C.sub.4 alkyl) or --CONH.sub.2 ;X is O, S, NH, N(C.sub.1 -C.sub.4 alkyl) or N(benzyl); andR, which is attached to the 5-, 6- or 7-position, is a group of the formula ##STR2## or (3- or 4-pyridyl)-Z.sup.2 - wherein Z.sup.1 is --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 O-- andZ.sup.2 is --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O-- or --OCH.sub.2 --;and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them.

Abstract: A series of novel 3-(pyrid-3- or -4-ylalkyl)-indoles useful as inhibitors of the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclo- oxygenase enzymes is disclosed.

Abstract: Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as heteroatoms a nitrogen atom and an additional oxygen or sulphur atom or up to three further nitrogen atoms; or a 6-membered heterocyclic group containing one or two nitrogen atoms;and the pharmaceutically acceptable acid addition salts thereof, are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclo-oxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes.

Abstract: Certain 2-(1-imidazolylmethyl)pyridine compounds, having a further substituent O--Y--Z at the 3- or 5-position of the pyridine ring. Y is --(CH.sub.2).sub.n --, --CH.sub.2 C.sub.6 H.sub.4 --, or --CH.sub.2 (Het)--, where n is an integer from 1 to 4 and Het is a heterocyclic group; Z is a carboxy (COOH) or carboxycarbonyl (COCOOH) group, or an ester or amide derivative thereof. The compounds of the invention selectively inhibit the thromboxane synthetase enzyme, without significantly inhibiting the action of the prostacyclic or cyclo-oxygenase enzymes in animals, including man. The compounds are useful, therefore, in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine and the vascular complications of diabetes.

Abstract: Novel 3-(1-Imidazolylalkyl)indoles and the pharmaceutically acceptable acid addition salts thereof are disclosed. The novel compounds are useful in selectively inhibiting the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus of value as therapeutic agents for the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes.

Abstract: Novel 2-(Imidazol-1-ylmethyl)pyrroles and pharmaceutically acceptable acid addition salts thereof are disclosed. The novel compounds are useful in selectively inhibiting the action of the thromboxane synthetase enzyme.

Abstract: 5-Substituted 2-pyrroleglyoxylic acids, L- and DI-5-substituted 2-pyrrolylglycines and their derivatives of the formulae ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein R is hydrogen or alkyl having from one to four carbon atoms;R.sup.1 is alkyl or alkylthio having one to ten carbon atoms, alkenyl having from three to six carbon atoms, cycloalkylthio having from five to seven carbon atoms or AR.sup.3 where A is a member bonded to the pyrrole ring and is alkylene or alkylenethio having from one to four carbon atoms or alkenylene having from two to four carbon atoms and R.sup.3 is cycloalkyl having from three to seven carbon atoms, cycloalkenyl having from five to seven carbon atoms or C.sub.6 H.sub.4 R.sup.4 where R.sup.4 is H, F, Cl, Br, I, alkyl or alkoxy, the latter two groups each having from one to four carbon atoms;R.sup.

Abstract: A series of 2-(imidazol-1-ylmethyl)pyridines and 2-(imidazol-1-ylmethyl)quinolines has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy for the treatment of ischaemic heart disease, migraine, transient ischaemic attack and stroke. Preferred member compounds include 2-(imidazol-1-ylmethyl)-3-methoxypyridine, 2-(imidazol-1-ylmethyl)-3-methoxy-6-methylpyridine and 2-(imidazol-1-ylmethyl)-3-benzyloxypyridine, respectively. Alternate methods of preparation are provided and the principal synthetic routes leading to the preferred compounds are described in some detail.

Abstract: A series of unsubstituted and substituted 3-(imidazol-1-ylalkyl)indole compounds has been prepared by reacting the appropriately substituted 3-methylindole starting material with imidazole per se, followed by further reaction with a proper acylating or alkylating agent of choice, if so desired. The resulting indole derivatives are useful in therapy for the treatment at ischaemic heart disease, migraine, transient ischaemic attack and stroke. Typical members include such preferred compounds as 3-(imidazol-1-ylmethyl)-1-methylindole and 3-(imidazol-1-ylmethyl)-2-isopropylindole, respectively.

Abstract: Novel-3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazoles having gastric anti-secretory activity are prepared. A typical embodiment is 3-tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole.

Abstract: Novel 3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazoles having gastric anti-secretory activity are prepared. A typical embodiment is 3-tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole.