Patents by Inventor Roger P. Simon

Roger P. Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and methods for preventing or reducing the incidence of transient ischemic attacks
    Patent number: 11826366
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Grant
    Filed: October 31, 2021
    Date of Patent: November 28, 2023
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • Treatment of ischemia
    Patent number: 11802140
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: October 31, 2023
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Roger P. Simon, Zhigang Xiong
  • METHOD AND SYSTEM OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASE AND SEIZURES
    Publication number: 20230250481
    Abstract: A method of distinguishing a subject with pre-clinical Alzheimer's disease from those with similar symptoms but other forms of dementia such as mild cognitive impairment. The blood RNA whole transcriptome profile of a subject with suspected pre-clinical Alzheimer's disease is obtained and analyzed against a reference blood RNA whole transcriptome profile from a subject with another form of dementia such as frontal temporal dementia, CADASIL or mild cognitive impairment (MCI). The blood RNA whole transcriptome profile includes the presence and quantitation of ncRNA. Methods to enhance treatment of epileptic seizures are also discussed.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 10, 2023
    Inventors: Robert MELLER, Roger P. SIMON
  • METHOD AND SYSTEM OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASE AND SEIZURES
    Publication number: 20230167503
    Abstract: A method of distinguishing a subject with pre-clinical Alzheimer's disease from those with similar symptoms but other forms of dementia such as mild cognitive impairment. The blood RNA whole transcriptome profile of a subject with suspected pre-clinical Alzheimer's disease is obtained and analyzed against a reference blood RNA whole transcriptome profile from a subject with another form of dementia such as frontal temporal dementia, CADASIL or mild cognitive impairment (MCI). The blood RNA whole transcriptome profile includes the presence and quantitation of ncRNA. Methods to enhance treatment of epileptic seizures are also discussed.
    Type: Application
    Filed: January 27, 2023
    Publication date: June 1, 2023
    Inventors: Robert MELLER, Roger P. SIMON
  • Composition for reducing nervous system injury and method of making and use thereof
    Patent number: 11559524
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 15, 2021
    Date of Patent: January 24, 2023
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • METHOD AND SYSTEM OF DIAGNOSING AND TREATING NEURODEGENERATIVE DISEASE AND SEIZURES
    Publication number: 20230010690
    Abstract: A method of distinguishing a subject with pre-clinical Alzheimer's disease from those with similar symptoms but other forms of dementia such as mild cognitive impairment. The blood RNA whole transcriptome profile of a subject with suspected pre-clinical Alzheimer's disease is obtained and analyzed against a reference blood RNA whole transcriptome profile from a subject with another form of dementia such as frontal temporal dementia, CADASIL or mild cognitive impairment (MCI). The blood RNA whole transcriptome profile includes the presence and quantitation of ncRNA. Methods to enhance treatment of epileptic seizures are also discussed.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 12, 2023
    Inventors: Robert Meller, Roger P. Simon
  • TREATMENT OF ISCHEMIA
    Publication number: 20220169685
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Application
    Filed: February 11, 2022
    Publication date: June 2, 2022
    Inventors: Roger P. SIMON, Zhigang XIONG
  • Treatment of ischemia
    Patent number: 11279738
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: March 22, 2022
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Roger P. Simon, Zhigang Xiong
  • COMPOSITION AND METHODS FOR PREVENTING OR REDUCING THE INCIDENCE OF TRANSIENT ISCHEMIC ATTACKS
    Publication number: 20220047586
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Application
    Filed: October 31, 2021
    Publication date: February 17, 2022
    Inventors: Zhigang XIONG, Roger P. SIMON
  • Composition and methods for preventing or reducing the incidence of transient ischemic attacks
    Patent number: 11160802
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 2, 2021
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF
    Publication number: 20210220354
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 15, 2021
    Publication date: July 22, 2021
    Inventors: Zhigang XIONG, Roger P. SIMON
  • Composition for reducing nervous system injury and method of making and use thereof
    Patent number: 10953006
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: March 23, 2021
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • TREATMENT OF ISCHEMIA
    Publication number: 20200354415
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Application
    Filed: June 17, 2020
    Publication date: November 12, 2020
    Inventors: Roger P. SIMON, Zhigang XIONG
  • Treatment of ischemia
    Patent number: 10766936
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: September 8, 2020
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Roger P. Simon, Zhigang Xiong
  • Treatment of ischemia
    Patent number: 10717771
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: July 21, 2020
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Roger P. Simon, Zhi-Gang Xiong
  • COMPOSITION AND METHODS FOR PREVENTING OR REDUCING THE INCIDENCE OF TRANSIENT ISCHEMIC ATTACKS
    Publication number: 20200188395
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 18, 2020
    Inventors: Zhigang Xiong, Roger P. Simon
  • Composition and methods for preventing or reducing the incidence of transient ischemic attacks
    Patent number: 10603316
    Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 31, 2020
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF
    Publication number: 20190365749
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 23, 2019
    Publication date: December 5, 2019
    Inventors: ZHIGANG XIONG, ROGER P. SIMON
  • Composition for reducing nervous system injury and method of making and use thereof
    Patent number: 10406156
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: September 10, 2019
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Zhigang Xiong, Roger P. Simon
  • TREATMENT OF ISCHEMIA
    Publication number: 20190270781
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Application
    Filed: April 23, 2019
    Publication date: September 5, 2019
    Inventors: Roger P. SIMON, Zhigang Xiong