Patents by Inventor Roger Pai

Roger Pai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apo-2 ligand/trail formulations
    Patent number: 8470969
    Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: June 25, 2013
    Assignee: Genentech, Inc.
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh, Evan E. Shave, Patricia A. Rancatore
  • Methods for making Apo-2 Ligand using divalent metal ions
    Publication number: 20120077740
    Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
    Type: Application
    Filed: December 10, 2010
    Publication date: March 29, 2012
    Applicant: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Sarah Hymowitz, Robert F. Kelley, Iphigenia Koumenis, Woon-Lam Susan Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
  • APO-2 LIGAND/TRAIL FORMULATIONS
    Publication number: 20110269947
    Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
    Type: Application
    Filed: June 23, 2010
    Publication date: November 3, 2011
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh, Evan E. Shave, Patricia A. Rancatore
  • APO-2 ligand/trail formulations
    Publication number: 20110245185
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Application
    Filed: October 21, 2010
    Publication date: October 6, 2011
    Applicant: Genentech, Inc.
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
  • METHOD OF PURIFYING APO-2 LIGAND/TRAIL USIN CRYSTALLISATION THE COLD
    Publication number: 20110054153
    Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
    Type: Application
    Filed: May 10, 2006
    Publication date: March 3, 2011
    Inventors: Heather Flores, Tanya Lin, Timothy Matthews, Roger Pai, Zahra Shahrokh
  • Methods for making Apo-2 ligand using divalent metal ions
    Patent number: 7855066
    Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: December 21, 2010
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Sarah Hymowitz, Robert F. Kelley, Iphigenia Koumenis, Woon-Lam Susan Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
  • Apo-2 ligand/trail formulations
    Patent number: 7842668
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: November 30, 2010
    Assignee: Genentech, Inc.
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
  • APO-2 ligand/trail formulations
    Patent number: 7741285
    Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: June 22, 2010
    Assignee: Genentech, Inc.
    Inventors: Heather Flores, Tanya P. Lin, Timothy C. Matthews, Roger Pai, Zahra Shahrokh
  • ApO2 ligand/TRAIL formulations
    Patent number: 7741282
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: June 22, 2010
    Assignee: Genentech, Inc.
    Inventors: Tanya P. Lin, Zahra Shahrokh, Heather Flores, Roger Pai, Timothy C. Matthews
  • Methods for making Apo-2 ligand using divalent metal ions
    Publication number: 20070161564
    Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 12, 2007
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, Sarah Hymowitz, Robert Kelley, Iphigenia Koumenis, Woon-Lam Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
  • Apo-2 ligand/trail formulations
    Publication number: 20060009387
    Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.
    Type: Application
    Filed: May 24, 2005
    Publication date: January 12, 2006
    Applicant: GENENTECH, INC.
    Inventors: Heather Flores, Tanya Lin, Timothy Matthews, Roger Pai, Zahra Shahrokh
  • Apo2 ligand/trail formulations
    Publication number: 20050080006
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Application
    Filed: November 12, 2002
    Publication date: April 14, 2005
    Inventors: Tanya Lin, Zahra Shahrokh, Heather Flores, Roger Pai, Timothy Matthews
  • Apo-2 ligand/trail formulations
    Publication number: 20050020498
    Abstract: The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.
    Type: Application
    Filed: February 3, 2004
    Publication date: January 27, 2005
    Inventors: Heather Flores, Tanya Lin, Timothy Matthews, Roger Pai, Zahra Shahrokh