Abstract: A plastic tape includes rare earth phosphors combined with fluorescent material, providing in low-light conditions unusual visibility of long duration. The extruded tape has tapered edges to hug the ground, and to promote aerodynamic movement, when suspended. The tape mid-section may have an irregularly corrugated, crenelated surface with a shirred, lace-like appearance on its intermediate surfaces. Proposed uses include vertical Venetian blinds; as a non-skid marking tape for boundaries or routes; as a cushioning elastic wrap for handles; and as an emergency “light” or marker for hospital corridors, aircraft aisles, emergency exit routes, and on the clothing of road workers, cyclists etc and the marking of boats and docks, marker buoys defining safe swimming areas, swimming pools, patios etc. Light reflectivity may be added by incorporating aluminium glitter material. Protection against ultra-violet (u/v) damage may also be incorporated.

Abstract: This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.

Abstract: This invention is directed to compounds of formula I ##STR1## wherein R.sup.1 is CN, CH.sub.2 CN, CH.dbd.CHCN, CHO, or CH.dbd.CHCO.sub.2 H;R.sup.2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio wherein each of the aryl and heteroaryl moieties is optionally substituted;R.sup.3 is halogen;R.sup.4 is optionally substituted aryl or optionally substituted heteroaryl;R.sup.5 is carboxy or an acid isostere;X is oxygen or sulphur; andn is zero or 1; or an N-oxide thereof, prodrug thereof solvate thereof, or pharmaceutically acceptable salt thereof, which compounds have endothelin antagonist activity. The invention is also directed to methods for preparing the compounds of formula I and their pharmaceutical use.