Abstract: A method for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing RNAi agents. A formulation for use in distributing RNAi molecules targeted to a human GST-? for treating a malignant tumor in a subject. The formulation may include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product may be made by lyophilization of the formulation.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

Abstract: A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs.

Abstract: A vehicle is provided that includes a cruise control deactivation system. The system includes a cruise control system, and a user control that, when activated, commands deactivation of the cruise control system. The system also includes a processor configured to permit or override the commanded deactivation of the cruise control system while the vehicle is moving, based on at least one criterion. Criteria may include whether or not a first sensor detects a foot of a driver of the vehicle on an accelerator pedal of the vehicle, and whether or not a first computation indicates that the deactivation of the cruise control system will cause a collision with a second vehicle located behind the vehicle.

Abstract: A method for matching a vehicle with a user including receiving a user ride request for a vehicle from a plurality of available vehicles from a user, receiving a threshold vehicle risk score preference for the user, receiving a user risk score for the user, receiving a threshold user risk score preference for the plurality of available vehicles, identifying a subset of the plurality of available vehicles having a vehicle risk score at or below the threshold vehicle risk score preference of the user and a threshold user risk score preference at or above the user risk score of the user, and presenting the user with ride options for selecting one of the subset of the plurality of available vehicles of the subset of available vehicles for the user ride request.

Abstract: Aspects of the disclosure are directed to automatically determining floor planning in chips, which factors in memory macro alignment. A deep reinforcement learning (RL) agent can be trained to determine optimal placements for the memory macros, where memory macro alignment can be included as a regularization cost to be added to the placement objective as a RL reward. Tradeoffs between the placement objective and alignment of macros can be controlled by a tunable alignment parameter.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: A method of predicting one or more road segment attributes corresponding to a road segment in a geographical area, the method including: providing trajectory data and satellite image of the geographical area; calculating one or more image channels based on the trajectory data; and using at least one processor, classi-fying the road segment based on the one or more image channels and the satellite image using a trained classifier into prediction probabil-ities of the road attributes A data processing system including one or more processors configured to carry out a the method of predicting road attributes. A computer executable code including instructions for predicting one or more road segment attributes according to the method.

Abstract: Systems and methods are provided for determining features in a vehicle. The interior of the vehicle can be scanned with a camera of a mobile device to locate one or more symbols or shapes within the interior. The one or more symbols or shapes can be processed using one or more machine learning models to obtain data associated with the one or more symbols or shapes. The data associated with the one or more symbols or shapes can be displayed to a driver of the vehicle.

Abstract: According to an aspect of the disclosure, a glass manufacturing system includes a hot-end subsystem, including: a submerged combustion melter that melts feedstock to produce molten glass; a stiller that receives the molten glass from the submerged combustion melter and that includes a stilling tank to still the molten glass and that is configured to control outflow of the stilled molten glass to effectively decouple viscosity of the molten glass from the flow rate of the molten glass and thereby control finer molten glass levels; and a finer that is mechanically decoupled from the stiller, and that receives and fines the stilled molten glass to produce fined molten glass. Many other aspects of the system are also disclosed and claimed.

Abstract: An adjustment cap assembly is provided. The adjustment cap assembly includes a disc with an top end, an opposed bottom end, and a side portion. The adjustment cap assembly includes an O-ring disposed about the disc, and a sleeve configured to secure the disc within the sleeve.

Abstract: An adjustment cap assembly is provided. The adjustment cap assembly includes a disc with an top end, an opposed bottom end, and a side portion. The adjustment cap assembly includes an O-ring disposed about the disc, and a sleeve configured to secure the disc within the sleeve.

Abstract: An interchangeable safety selector, including at least some of a generally cylindrical lock member rotatable between at least a safe and at least one fire position; at least one recess formed in each end of the lock member; and at least two lever members, each lever member having at least one projection mateable with the at least one recess of the lock member, wherein the lever members are interchangeable, and wherein at least one of the lever members is securable to a first end of the lock member via interaction of the at least one projection and the at least one recess.

Abstract: An interchangeable safety selector that includes a generally cylindrical lock member rotatable between a safe and a fire position, wherein when the lock member is in the safe position a first portion of the lock member blocks movement of a portion of a firing mechanism of a firearm; a projection formed on each end of the lock member; and at least two lever members, each lever member having a recess mateable with the projection of the lock member, wherein the lever members are interchangeable, wherein one of the lever members is secured to a first end of the lock member via interaction of the projection and the recess and is further secured to the first end of the lock member via a screw.

Abstract: A pin that includes a head and a shank that extends from a shoulder of the head to a terminal surface. A primary channel is formed in a portion of the pin and extends from a portion of the head, along a longitudinal axis of the pin, into a portion of the shank. The primary channel includes a primary recess formed proximate each end of the primary channel. An installation channel is formed in a portion of the pin that extends from a portion of the primary channel, along a longitudinal axis of the pin, towards the terminal surface. The installation channel includes an installation recess formed proximate an end of the installation channel.