Patents by Inventor Roger Wermuth

Roger Wermuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
    Publication number: 20250127780
    Abstract: The invention relates to a compound of formula (I) wherein L, A1, A2, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 18, 2024
    Publication date: April 24, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guillaume DÉCORET, Katrin GROEBKE ZBINDEN, Wolfgang HAAP, Lukas KREIS, Xavier LUCAS CABRÉ, Jean-Yves WACH, Roger WERMUTH
  • Benzimidazole Pyridine Derivatives
    Publication number: 20240383875
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2?, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mahendra AWALE, Stefan BERCHTOLD, Julie CHARPENTIER, Héloïse Marie Albine COLOMBANO, Guillaume DECORET, Katrin GROEBKE ZBINDEN, Nicole GROSSMANN, Wolfgang HAAP, Philip Anthony HARRIS, Jérôme HERT, Jonah Milton KALLENBACH, Christian KRAMER, Lukas KREIS, Danny KRUMM, Xavier LUCAS CABRE, Nenad MANEVSKI, Philippe PFLIEGER, Amir Mohsen POURMOUSA ABKENAR, Etienne RAUBER, Dazhi TAN, Jean-Yves WACH, Roger WERMUTH
  • BACE1 inhibitors
    Patent number: 11447478
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: September 20, 2022
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Hans Hilpert, Roland Humm, Thorsten Muser, Christian Schnider, Roger Wermuth, Thomas Woltering
  • Pyridyl-triazabicycles
    Patent number: 10829500
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: November 10, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • PYRIDYL-TRIAZABICYCLES
    Publication number: 20190352312
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Application
    Filed: July 31, 2019
    Publication date: November 21, 2019
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • Pyridyl-triazabicycles
    Patent number: 10414780
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: September 17, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • PYRIDYL-TRIAZABICYCLES
    Publication number: 20180312528
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 1, 2018
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • Pyridyl-triazabicycles
    Patent number: 10047102
    Abstract: The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: August 14, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • PYRIDYL-TRIAZABICYCLES
    Publication number: 20180194779
    Abstract: The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Application
    Filed: July 21, 2015
    Publication date: July 12, 2018
    Inventors: Bjoern Bartels, Cosimo Dolente, Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Ulrike Obst Sander, Jens-Uwe Peters, Mark Rogers-Evans, Thomas Woltering, Christian Schnider, Roger Wermuth
  • 5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
    Patent number: 9605006
    Abstract: The present invention provides a compound of formula I? having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: March 28, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Jens-Uwe Peters, Ulrike Obst Sander, Christian Schnider, Roger Wermuth, Thomas Woltering
  • 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES
    Publication number: 20160318952
    Abstract: The present invention provides a compound of formula I? having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Guba, Wolfgang Haap, Andreas Kuglstatter, Jens-Uwe Peters, Ulrike Obst Sander, Christian Schnider, Roger Wermuth, Thomas Woltering
  • BACE1 INHIBITORS
    Publication number: 20160052920
    Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
    Type: Application
    Filed: April 8, 2014
    Publication date: February 25, 2016
    Applicants: HOFFMANN-LA ROCHE INC., SIENA BIOTECH S.p.A.
    Inventors: Hans Hilpert, Roland Humm, Thorsten Muser, Christian Schnider, Roger Wermuth, Thomas Woltering