Patents by Inventor Rogers Yocum

Rogers Yocum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microorganisms and assays for the identification of antibiotics
    Publication number: 20080160551
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Application
    Filed: February 22, 2007
    Publication date: July 3, 2008
    Applicant: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7291489
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: November 6, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Microorganisms and processes for enhanced production of pantothenate
    Patent number: 7244593
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: July 17, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: R. Roger Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Processes for enhanced production of pantothenate
    Patent number: 7220561
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Grant
    Filed: January 19, 2002
    Date of Patent: May 22, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Roger Yocum, Kai-Uwe Baldenius, Christine Beck
  • Biotin biosynthesis in bacillus subtilis
    Patent number: 6841366
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: January 11, 2005
    Assignee: DSM IP Assets B.V.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
  • Microorganisms and assays for the identification of antibiotics
    Patent number: 6830898
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: December 14, 2004
    Assignee: OmniGene Bioproducts, Inc.
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • Microorganisms and processes for enhanced production of pantothenate
    Publication number: 20040146996
    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 3, 2003
    Publication date: July 29, 2004
    Inventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
  • Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
    Publication number: 20040146997
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. The method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Application
    Filed: January 9, 2004
    Publication date: July 29, 2004
    Applicant: ROCHE VITAMINS, INC.
    Inventors: Scott W. Van Arsdell, R. Rogers Yocum, John B. Perkins, Janice G. Pero
  • Overcoming DAPA aminotransferase bottlenecks in biotin vitamers biosynthesis
    Patent number: 6737256
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: May 18, 2004
    Assignee: Roche Vitamins Inc.
    Inventors: Scott W. Van Arsdell, R. Rogers Yocum, John B. Perkins, Janice G. Pero
  • Processes for enhanced production of pantothenate
    Publication number: 20040086982
    Abstract: The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
    Type: Application
    Filed: July 18, 2003
    Publication date: May 6, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Method and microorganisms for the production of 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (hmbpa)
    Publication number: 20040048343
    Abstract: The present invention features methods of producting 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid (“HMBPA”) and &agr;-hydroxyisovalerate (“&agr;-HIV”) utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including &agr;-HIV.
    Type: Application
    Filed: July 18, 2003
    Publication date: March 11, 2004
    Inventors: Theron Hermann, Thomas A. Patterson, Janice G. Pero, R. Rogers Yocum, Kai-Uwe Baldenius, Christine Beck
  • Microorganisms and assays for the identification of antibiotics
    Publication number: 20020168681
    Abstract: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification of CoaX modulators. Also featured are coaX nucleic acid molecules and purified CoaX proteins, as well as recombinant vectors and microorganisms including the gene, coaX.
    Type: Application
    Filed: March 20, 2001
    Publication date: November 14, 2002
    Inventors: R. Rogers Yocum, Thomas A. Patterson
  • OVERCOMING DAPA AMINOTRANSFERASE BOTTLENECKS IN BIOTIN VITAMERS BIOSYNTHESIS
    Publication number: 20020098556
    Abstract: A method is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. This method involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.
    Type: Application
    Filed: July 14, 1997
    Publication date: July 25, 2002
    Inventors: SCOTT W. VAN ARSDELL, R. ROGERS YOCUM, JOHN B. PERKINS, JANICE G. PERO
  • Biotin biosynthesis in bacillus subtilis
    Patent number: 6303377
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: October 16, 2001
    Assignee: Roche Vitamins Inc.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero
  • Yeast vectors conferring antibiotic resistance
    Patent number: 6214577
    Abstract: A vector having a gene for resistance to an antibiotic otherwise capable of killing a host yeast cell, the gene being transcribed from a yeast promoter sequence.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 10, 2001
    Inventor: Robert Rogers Yocum
  • Biotin biosynthesis in Bacillus subtilis
    Patent number: 6057136
    Abstract: The invention generally provides the genes of the biotin biosynthetic operon of Bacillus subtilis, and closely related species thereof, and well as constructions useful for high level production of biotin.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: May 2, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Stanley Grant Bower, John B. Perkins, R. Rogers Yocum, Janice G. Pero