Patents by Inventor Rogier Bertina

Rogier Bertina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods
    Patent number: 5405946
    Abstract: The present invention describes a variant protein S protein that is substantially homologous in amino acid residue sequence to wild-type mature human protein S, which has in vitro anticoagulant activity and has a reduced ability to bind C4b binding protein (C4BP), compositions containing the variant protein S, and recombinant DNA vectors for expressing the variant protein. Also disclosed are therapeutic methods of using variant protein S for inhibiting thrombosis, inflammation and the like conditions ameliorated by protein S.
    Type: Grant
    Filed: December 2, 1992
    Date of Patent: April 11, 1995
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Bonno N. Bouma, Rogier Bertina