Patents by Inventor Rogier Christiaan BUIJSMAN

Rogier Christiaan BUIJSMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROGNOSTIC BIOMARKERS FOR TTK INHIBITOR CHEMOTHERAPY
    Publication number: 20220056540
    Abstract: A method for identifying a tumor that is susceptible to treatment with a TTK inhibitor, including: a) providing a sample of a tumor; b) determining the presence of a mutated CTNNB1 gene in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 gene indicates the tumor is susceptible to treatment with a TTK inhibitor. Alternatively, step b) is replaced by the step of determining the presence of a mutated CTNNB1 protein in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 protein indicates the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b) includes determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates the tumor is susceptible to treatment with a TTK inhibitor.
    Type: Application
    Filed: November 9, 2021
    Publication date: February 24, 2022
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Jeroen DE ROOS, Joost Cornelis Marinus UITDEHAAG, Adrianus Petrus Antonius DE MAN, Rogier Christiaan BUIJSMAN, Guido Jenny Rudolf ZAMAN
  • Prognostic biomarkers for TTK inhibitor chemotherapy
    Patent number: 11208696
    Abstract: A method for identifying a tumor that is susceptible to treatment with a TTK inhibitor, including: a) providing a sample of a tumor; b) determining the presence of a mutated CTNNB1 gene in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 gene indicates the tumor is susceptible to treatment with a TTK inhibitor. Alternatively, step b) is replaced by the step of determining the presence of a mutated CTNNB1 protein in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 protein indicates the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b) includes determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates the tumor is susceptible to treatment with a TTK inhibitor.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: December 28, 2021
    Assignee: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Jeroen De Roos, Joost Cornelis Marinus Uitdehaag, Adrianus Petrus Antonius De Man, Rogier Christiaan Buijsman, Guido Jenny Rudolf Zaman
  • PROGNOSTIC BIOMARKERS FOR TTK INHIBITOR CHEMOTHERAPY
    Publication number: 20190211401
    Abstract: A method for identifying a tumor that is susceptible to treatment with a TTK inhibitor, including: a) providing a sample of a tumor; b) determining the presence of a mutated CTNNB1 gene in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 gene indicates the tumor is susceptible to treatment with a TTK inhibitor. Alternatively, step b) is replaced by the step of determining the presence of a mutated CTNNB1 protein in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 protein indicates the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b) includes determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates the tumor is susceptible to treatment with a TTK inhibitor.
    Type: Application
    Filed: April 14, 2016
    Publication date: July 11, 2019
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Jeroen DE ROOS, Joost Cornelis Marinus UITDEHAAG, Adrianus Petrus Antonius DE MAN, Rogier Christiaan BUIJSMAN, Guido Jenny Rudolf ZAMAN