Abstract: The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.

Abstract: The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.

Abstract: The invention relates to novel specifically expressed proteins, and to nucleic acid sequences or recombinant nucleic acid constructs encoding said proteins. The invention further relates to host organisms or transgenic animals containing said nucleic acid sequences or recombinant nucleic acid constructs, and to monoclonal or polyclonal antibodies directed to the isolated proteins. The invention also relates to a method for finding substances having a specific binding affinity to the inventive proteins, and to a method for the qualitative or quantitative analysis of the inventive nucleic acid sequences or inventive proteins. The invention further relates to the use of the nucleic acid sequences and proteins.

Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

Abstract: The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.

Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.

Abstract: The present invention relates to nucleic acid sequences and isolated proteins which are novel interaction partners for inwardly rectifying potassium channels (Kirs), in particular G protein-coupled inwardly rectifying potassium channels (GIRKs). These interaction partners form protein complexes together with Kirs and GIRKs. The invention further relates to a charged domain of the novel interaction partners which binds to the complex intracellular region of Kirs and influences the activity of Kirs in general or of GIRKS in particular. The invention additionally relates to protein complexes composed of interaction partners and inwardly rectifying potassium channels, nucleic acid sequences or recombinant nucleic acid constructs which code for such proteins or domains, and the uses thereof. The invention additionally relates to protein complexes composed of the novel proteins with other proteins.