Patents by Inventor Rohini Muthuswami

Rohini Muthuswami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives
    Patent number: 6573060
    Abstract: Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 3, 2003
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel W. Hockensmith, Rohini Muthuswami
  • Mammalian DNA-dependent ATPase a polypeptides and fusions thereof
    Patent number: 6537791
    Abstract: Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 25, 2003
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel W. Hockensmith, Rohini Muthuswami
  • Polynucleotides encoding mammalian DNA-dependent ATPase A polypeptides
    Patent number: 6531306
    Abstract: Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 11, 2003
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel W. Hockensmith, Rohini Muthuswami
  • Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives
    Patent number: 6180612
    Abstract: Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: January 30, 2001
    Assignee: The University of Virginia Patent Foundation
    Inventors: Joel W. Hockensmith, Rohini Muthuswami