Abstract: Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at ?10 to 10° C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at ?10 to 10° C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone.

Abstract: A continuous micromixer based process for the synthesis of sulphoxide compounds with a reaction time of less than or equal one minute is disclosed. The process shows selectivity of >95% towards the sulphoxide compounds.

Abstract: The present invention relates to a process for the preparation of [S(?) amlodipine-L(+)-hemi taratarte] from RS amlodipine base using L(+) tartaric acid in the presence of dimethyl sulfoxide.

Abstract: The present invention provides a process for preparation of optically active azabicyclo heptanone derivates using lactamases that will react with racemic lactam of formula (I) to give a single enanotiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.

Abstract: The present invention relates to a process for the preparation of [S(−)amlodipine-L(+)-hemi taratarte] from RS amlodipine base using L(+) tartaric acid in the presence of dimethyl sulfoxide.

Abstract: A process for the preparation of S(−) Amlodipine salts which comprises reaction of S(−)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol methanol 2 propanol hydrocarbons like toluene and polar solvent like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(−) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.

Abstract: The present invention provides a process for preparation of optically active azabicyclo heptanone derivatives using lactamases that will react with racemic −lactam of formula (I) to give a single enantiomer of lactam (III) and the corresponding ring opened compound of formula (IV) in an enantiomerically pure form.

Abstract: The present invention provides a method to prepare alkyl-4-[2(phthalimido)-ethoxy]-acetoacetate which are useful in the manufacture of anti-hypertensive and anti-ischaemic drugs by reacting 2(phthalimido)-ethoxyacetic acid with thionyl chloride and then reacting the acid chloride product obtained with Meldrums acid.

Abstract: The present invention relates to a process for the preparation of 4-(R)-hydroxycyclopent-2-en-1 (S)-acetate of the formula 2 by reacting meso-cyclopent-2-en-1, 4-diacetate of formula 1 with a whole cell enzyme in a mixture of a buffer and an organic solvent, filtering the reaction mixture to remove the enzyme, extracting the resultant compound with an organic solvent, and removing the solvent to obtain the desired product.

Abstract: A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial Microorganisms (NCIM), National Chemical Laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30° C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Abstract: The present invention relates to a process for the preparation of D(-)N-carbamoylphenylglycine, by growing Pseudomonas sp deposited at National Collection of Industrial Microorganisms, Pune, India and at American Type Cultural Centre, Rockville, U.S.A and afforded accession No. ATCC 55940 in a conventional nutrient, medium, suspending the cells in alkaline buffer containing buffer, acidifying the broth to obtain the product.

Abstract: A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial microorganisms (NCIM), National Chemical laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30.degree. C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.