Patents by Inventor Rohit Karnik
Rohit Karnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11833255Abstract: Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.Type: GrantFiled: October 7, 2016Date of Patent: December 5, 2023Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute Of TechnologyInventors: Sunandini Chopra, Rohit Karnik, Amy Wang, Omid C. Farokhzad, Xue-Qing Zhang
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Patent number: 11726015Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.Type: GrantFiled: August 3, 2021Date of Patent: August 15, 2023Assignee: Massachusetts Institute of TechnologyInventors: Emily Hanhauser, Michael Bono, Anastasios John Hart, Rohit Karnik, Xiaoyuan Ren, Chintan Vaishnav
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Publication number: 20210364398Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.Type: ApplicationFiled: August 3, 2021Publication date: November 25, 2021Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Emily Hanhauser, Michael Bono, Anastasios John Hart, Rohit Karnik, Xiaoyuan Ren, Chintan Vaishnav
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Patent number: 11131609Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.Type: GrantFiled: April 26, 2017Date of Patent: September 28, 2021Assignee: Massachusetts Institute of TechnologyInventors: Emily Hanhauser, Michael Bono, Anastasios John Hart, Rohit Karnik, Xiaoyuan Ren, Chintan Vaishnav
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Publication number: 20180318230Abstract: Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.Type: ApplicationFiled: October 7, 2016Publication date: November 8, 2018Inventors: Sunandini Chopra, Rohit Karnik, Amy Wang, Omid C. Farokhzad, Xue-Qing Zhang
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Patent number: 9931410Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.Type: GrantFiled: October 9, 2013Date of Patent: April 3, 2018Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of TechnologyInventors: Pedro M. Valencia, Eric M. Pridgen, Suresh Gadde, Rohit Karnik, Robert S. Langer, Stephen J. Lippard, Omid C. Farokhzad
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Patent number: 9873092Abstract: The present invention relates to a material. In particular, it relates to a membrane for filtering water. More particularly, it relates to a membrane comprising carbon nanotubes and mixed cellulose ester porous membranes for water desalination and purification. Still more particular, the membrane comprising a fibrous substrate and carbon nanotubes formed on a fibrous substrate, wherein the surface of the carbon nanotubes is functionally modified. A microfluidic device comprising such a membrane and a method for filtering water are also disclosed.Type: GrantFiled: May 20, 2013Date of Patent: January 23, 2018Assignees: Singapore University of Technology, Massachusetts Institute of TechnologyInventors: Hui Ying Yang, Rohit Karnik
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Publication number: 20170322127Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.Type: ApplicationFiled: April 26, 2017Publication date: November 9, 2017Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Emily Hanhauser, Michael Bono, Anastasios John Hart, Rohit Karnik, Xiaoyuan Ren, Chintan Vaishnav
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Patent number: 9381477Abstract: The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.Type: GrantFiled: June 22, 2007Date of Patent: July 5, 2016Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Rohit Karnik, Frank X. Gu, Pamela Basto, Chris Cannizzaro, Alireza Khademhosseini, Robert S. Langer, Omid C. Farokhzad
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Publication number: 20150265716Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.Type: ApplicationFiled: October 9, 2013Publication date: September 24, 2015Inventors: Pedro M. Valencia, Eric M. Pridgen, Suresh Gadde, Rohit Karnik, Robert S. Langer, Stephen J. Lippard, Omid C. Farokhzad
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Publication number: 20150122735Abstract: The present invention relates to a material. In particular, it relates to a membrane for filtering water. More particularly, it relates to a membrane comprising carbon nanotubes and mixed cellulose ester porous membranes for water desalination and purification. Still more particular, the membrane comprising a fibrous substrate and carbon nanotubes formed on a fibrous substrate, wherein the surface of the carbon nanotubes is functionally modified. A microfluidic device comprising such a membrane and a method for filtering water are also disclosed.Type: ApplicationFiled: May 20, 2013Publication date: May 7, 2015Inventors: Hui Ying Yang, Rohit Karnik
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Patent number: 8440453Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.Type: GrantFiled: January 3, 2008Date of Patent: May 14, 2013Assignee: The Regents of the University of CaliforniaInventors: Peidong Yang, Rohit Karnik, Kenneth Castelino, Rong Fan, Arun Majumdar
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Publication number: 20120171778Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.Type: ApplicationFiled: January 3, 2008Publication date: July 5, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Peidong Yang, Rohit Karnik, Kenneth Castelino, Rong Fan, Arun Majumdar
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Patent number: 7898005Abstract: Nanofluidic devices incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or bio-chemical species are described. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage.Type: GrantFiled: December 15, 2008Date of Patent: March 1, 2011Assignee: The Regents of the University of CaliforniaInventors: Peidong Yang, Arunava Majumdar, Rong Fan, Rohit Karnik
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Publication number: 20100022680Abstract: The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.Type: ApplicationFiled: June 22, 2007Publication date: January 28, 2010Inventors: Rohit Karnik, Frank X. Gu, Pamela Basto, Chris Cannizzaro, Alireza Khademhosseini, Robert S. Langer, Omid C. Farokhzad
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Publication number: 20090283751Abstract: Nanofluidic devices incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or biochemical species are described. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage.Type: ApplicationFiled: December 15, 2008Publication date: November 19, 2009Inventors: Peidong Yang, Arunava Majumdar, Rong Fan, Rohit Karnik
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Publication number: 20090056917Abstract: A heat pipe comprising a chamber; a wick in the chamber, and a heat sink, which is adjacent to a first portion of the wick. A heat source adjacent to a second portion of the wick, wherein the wick is configured such that a gas condenses at the first portion of the wick and a liquid evaporates at the second portion of the wick. The fluid moves from the first portion of the wick to the second portion of the wick, and wherein the wick comprises nanostructures having a differentially-spaced apart gradient along the length of the wick so as to promote capillary fluid flow therealong.Type: ApplicationFiled: August 9, 2006Publication date: March 5, 2009Applicant: The Regents of the University of CaliforniaInventors: Arun Majumdar, Rohit Karnik, Woochul Kim