Patents by Inventor Rohit Kolhatkar

Rohit Kolhatkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting NAD biosynthesis in bacterial pathogens
    Patent number: 8785499
    Abstract: The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: July 22, 2014
    Assignees: University of Maryland, Baltimore, The Board of Regents of the University of Texas System, Sanford-Burnham Medical Research Institute
    Inventors: Alexander Mackerell, Jr., Hong Zhang, Andrei Osterman, Rohit Kolhatkar
  • TARGETING NAD BIOSYNTHESIS IN BACTERIAL PATHOGENS
    Publication number: 20120190708
    Abstract: The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes.
    Type: Application
    Filed: July 12, 2010
    Publication date: July 26, 2012
    Applicants: UNIVERSITY OF MARYLAND, BALTIMORE, The Board of Regents of the University of the University of Texas System, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Alexander Mackerell, JR., Hong Zhang, Andrei Osterman, Rohit Kolhatkar