Abstract: Improved systems and methods are provided herein for extracting target speech from audio signals that can contain masking speech or other unwanted noise content. These systems and methods include detection of target speech in an input signal by detecting elevated frequency content in the signal above a threshold frequency. Portions of the signal determined to contain such elevated high frequency content are then used to generate audio filters to extract target speech from subsequently-obtained audio signals. This can include performing non-negative matrix factorization to determine a set of basis vectors to represent noise content in the spectral domain and then using the set of basis vectors to decompose subsequently-obtained audio signals into noise signals that can then be removed from the audio signals.