Patents by Inventor Rohit N. Karnik
Rohit N. Karnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230249974Abstract: Atomically thin layers including pores, their method of manufacture, and their use are disclosed. In some embodiments, pores may be formed in an atomically thin layer by growing the atomically thin layer on exposed portions of a substrate that includes islands comprising a material that is different than the material of the substrate. In some embodiments, pores and/or defects may be formed in an atomically thin layer by employing growth conditions that promote the formation of defects and/or pores. In certain embodiments, pores and/or defects may be etched to enlarge their size.Type: ApplicationFiled: November 3, 2022Publication date: August 10, 2023Applicants: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Piran Kidambi, Ahmed Ibrahim, Tahar Laoui, Jing Kong, Rohit N Karnik, Sui Zhang
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Patent number: 11717791Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: GrantFiled: April 27, 2020Date of Patent: August 8, 2023Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Suman Bose, Michael S. H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Patent number: 11524898Abstract: Atomically thin layers including pores, their method of manufacture, and their use are disclosed. In some embodiments, pores may be formed in an atomically thin layer by growing the atomically thin layer on exposed portions of a substrate that includes islands comprising a material that is different than the material of the substrate. In some embodiments, pores and/or defects may be formed in an atomically thin layer by employing growth conditions that promote the formation of defects and/or pores. In certain embodiments, pores and/or defects may be etched to enlarge their size.Type: GrantFiled: November 3, 2017Date of Patent: December 13, 2022Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Piran Kidambi, Ahmed Ibrahim, Tahar Laoui, Jing Kong, Rohit N. Karnik, Sui Zhang
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Patent number: 11135546Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. The filters may include at least one active layer disposed on a porous substrate. The at least one active layer may include intrinsic and/or intentional formed pores. In some embodiments, the flow resistance of the porous substrate may be selected to limit flow through defects and intrinsic pores in the at least one active layer.Type: GrantFiled: March 15, 2013Date of Patent: October 5, 2021Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Sean C. O'Hern, Michael S. H. Boutilier, Cameron A. Stewart, Harold S. Au, Nicolas G. Hadjiconstantinou, Tahar Laoui, Muataz A. Atieh
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Publication number: 20200316528Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: ApplicationFiled: April 27, 2020Publication date: October 8, 2020Applicants: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Suman Bose, Michael S.H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Patent number: 10668435Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: GrantFiled: January 23, 2018Date of Patent: June 2, 2020Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Suman Bose, Michael S. H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Publication number: 20200062600Abstract: Atomically thin layers including pores, their method of manufacture, and their use are disclosed. In some embodiments, pores may be formed in an atomically thin layer by growing the atomically thin layer on exposed portions of a substrate that includes islands comprising a material that is different than the material of the substrate. In some embodiments, pores and/or defects may be formed in an atomically thin layer by employing growth conditions that promote the formation of defects and/or pores. In certain embodiments, pores and/or defects may be etched to enlarge their size.Type: ApplicationFiled: November 3, 2017Publication date: February 27, 2020Applicants: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Piran Kidambi, Ahmed Ibrahim, Tahar Laoui, Jing Kong, Rohit N. Karnik, Sui Zhang
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Publication number: 20200001245Abstract: Disclosed embodiments are related to mitigating leaks in membranes and/or improving the selectivity of membranes.Type: ApplicationFiled: June 28, 2019Publication date: January 2, 2020Applicant: Massachusetts Institute of TechnologyInventors: Rohit N. Karnik, Doojoon Jang
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Patent number: 10226427Abstract: Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.Type: GrantFiled: March 16, 2016Date of Patent: March 12, 2019Assignee: Massachusetts Institute of TechnologyInventors: Ambika Goel Bajpayee, Alan Grodzinsky, Cliff Richard Wong, Moungi G. Bawendi, Rohit N. Karnik
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Patent number: 10065154Abstract: Devices and methods integrate nanopore and microfluidic technologies for recording molecular characteristics of individual molecules such as, for example, biomolecules. Devices comprise a first substrate comprising a microchannel, a second substrate comprising a microchannel, the second substrate positioned below the first substrate, and a membrane having a thickness of about 0.3 nm to about 1 nm and comprising at least one nanopore, the membrane positioned between the first substrate and the second substrate, wherein a single nanopore of the membrane is constructed and arranged for electrical and fluid communication between the microchannel of the first substrate and the microchannel of the second substrate. To mitigate the effect of errors that occur during de novo DNA synthesis, longer DNA molecules are typically synthesized from shorter oligonucleotides by polymerase construction and amplification (PCA), or by other methods.Type: GrantFiled: October 4, 2013Date of Patent: September 4, 2018Assignee: Massachusetts Institute of TechnologyInventors: Carlos Andres Aguilar, Tarun Kumar Jain, Rohit N. Karnik, Peter A. Carr
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Publication number: 20180185791Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: ApplicationFiled: January 23, 2018Publication date: July 5, 2018Applicants: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Suman Bose, Michael S.H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Patent number: 9901879Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: GrantFiled: October 31, 2014Date of Patent: February 27, 2018Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Rohit N. Karnik, Suman Bose, Michael S. H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Publication number: 20160296471Abstract: Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.Type: ApplicationFiled: March 16, 2016Publication date: October 13, 2016Applicant: Massachusetts Institute of TechnologyInventors: Ambika Goel Bajpayee, Alan Grodzinsky, Cliff Richard Wong, Moungi G. Bawendi, Rohit N. Karnik
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Patent number: 9289506Abstract: Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.Type: GrantFiled: January 6, 2014Date of Patent: March 22, 2016Assignee: Massachusetts Institute of TechnologyInventors: Ambika Goel Bajpayee, Alan Grodzinsky, Cliff Richard Wong, Moungi G. Bawendi, Rohit N. Karnik
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Publication number: 20150283514Abstract: Devices and methods integrate nanopore and microfluidic technologies for recording molecular characteristics of individual molecules such as, for example, biomolecules. Devices comprise a first substrate comprising a microchannel, a second substrate comprising a microchannel, the second substrate positioned below the first substrate, and a membrane having a thickness of about 0.3 nm to about 1 nm and comprising at least one nanopore, the membrane positioned between the first substrate and the second substrate, wherein a single nanopore of the membrane is constructed and arranged for electrical and fluid communication between the microchannel of the first substrate and the microchannel of the second substrate. To mitigate the effect of errors that occur during de novo DNA synthesis, longer DNA molecules are typically synthesized from shorter oligonucleotides by polymerase construction and amplification (PCA), or by other methods.Type: ApplicationFiled: October 4, 2013Publication date: October 8, 2015Applicant: Massachusetts Institute of TechnologyInventors: Carlos Andres Aguilar, Tarun Kumar Jain, Rohit N. Karnik, Peter A. Carr
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Publication number: 20150122727Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.Type: ApplicationFiled: October 31, 2014Publication date: May 7, 2015Applicants: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: ROHIT N. KARNIK, Suman Bose, Michael S.H. Boutilier, Nicolas G. Hadjiconstantinou, Tarun Kumar Jain, Sean C. O'Hern, Tahar Laoui, Muataz A. Atieh, Doojoon Jang
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Publication number: 20140227777Abstract: The present disclosure, among other things, describes cell rolling by 3D flow and adhesive rolling. In some embodiments, a device described herein includes a flow channel dimensioned to permit fluid flow therethrough; at least one 3D structure protruding from at least one surface of the flow channel; and at least one cell adhesion entity coated on at least part of at least one of the 3D structures, which adhesion entity interacts with a target cell brought into contact with the 3D structures by flow of a stream comprising the target cell through the flow channel such that the target cell's trajectory through the flow channel is diverted due to the interaction.Type: ApplicationFiled: October 1, 2012Publication date: August 14, 2014Applicant: Brigham and Women's HospitalInventors: Sung Young Choi, Rohit N. Karnik, Jeffrey M. Karp
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Patent number: 8652332Abstract: Method and devices for filtering liquid are provided that rely on pressure difference to filter liquid. In one embodiment, a device for filtering liquid includes a feed chamber, a permeate chamber, and a porous membrane that is at least partially hydrophobic and has one or more pores configured to be permeable to vapor. A pressure of a liquid substance in the feed chamber is increased such that vapor of the liquid substance is transported from the feed chamber to the permeate chamber. The resistance of flow in a hydrophilic layer of the membrane can be controlled to make the membrane defect-tolerant. In another embodiment, a second porous membrane is further included and the second porous membrane is spaced apart from the first porous membrane. Various methods for filtering liquid are also provided.Type: GrantFiled: January 11, 2010Date of Patent: February 18, 2014Assignee: Massachusetts Institute of TechnologyInventors: Rohit N. Karnik, Jongho Lee
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Publication number: 20130331792Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises one or more tips, wherein the one or more tips are designed and constructed to initiate penetration by the device; and one or more protrusions in a region adjacent to each tip. In some embodiments, one or more protrusions can be constructed and arranged so that the required penetration force is reduced as compared with that observed for an otherwise identical device lacking the one or more protrusions. Additionally or alternatively, one or more protrusions can be constructed and arranged such that the required pull-out force is increased as compared with that observed for an otherwise identical device lacking the one or more protrusions.Type: ApplicationFiled: January 18, 2012Publication date: December 12, 2013Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Jeffrey M. Karp, Woo Kyung Cho, Bryan Laulicht, James A. Ankrum, Rohit N. Karnik, Robert Langer
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Publication number: 20100176057Abstract: Method and devices for filtering liquid are provided that rely on pressure difference to filter liquid. In one embodiment, a device for filtering liquid includes a feed chamber, a permeate chamber, and a porous membrane that is at least partially hydrophobic and has one or more pores configured to be permeable to vapor. A pressure of a liquid substance in the feed chamber is increased such that vapor of the liquid substance is transported from the feed chamber to the permeate chamber. The resistance of flow in a hydrophilic layer of the membrane can be controlled to make the membrane defect-tolerant. In another embodiment, a second porous membrane is further included and the second porous membrane is spaced apart from the first porous membrane. Various methods for filtering liquid are also provided.Type: ApplicationFiled: January 11, 2010Publication date: July 15, 2010Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Rohit N. Karnik, Jongho Lee