Abstract: A composition for administration to a subject with dry eye or a dry eye-associated ocular condition is disclosed. The composition includes a botanical active agent in an amount effective for treating, preventing, and/or ameliorating dry eye or a dry eye-associated ocular condition in a subject upon administration of the composition thereto. The botanical active agent comprises a Zingiber officinale extract, an Eriobotrya japonica extract, or combinations thereof. The composition may be adapted for oral administration to the subject, and formulated as a nutraceutical, pharmaceutical, or supplement, e.g. in a single dosage form of a capsule or softgel. A method of treating, preventing, and/or ameliorating dry eye or a dry eye-associated ocular condition in a subject is also disclosed. The method comprises administering an effective amount of the composition to a subject.