Patents by Inventor Roi Gazit

Roi Gazit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TUMOR ENVIRONMENT SPECIFIC EXPRESSION OF EFFECTOR GENES
    Publication number: 20220315640
    Abstract: A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence of a synthetic promoter, comprising two or more promoter-response-elements inducing expression of an immune-effector gene.
    Type: Application
    Filed: March 21, 2022
    Publication date: October 6, 2022
    Inventors: Roi GAZIT, Angel PORGADOR
  • TUMOR ENVIRONMENT-SPECIFIC EXPRESSION OF CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20210030799
    Abstract: A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter-response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF-tumor hazard.
    Type: Application
    Filed: February 14, 2019
    Publication date: February 4, 2021
    Inventors: Angel PORGADOR, Roi GAZIT
  • Hematopoietic stem cell specific reporter mouse and uses thereof
    Patent number: 10080354
    Abstract: Described herein are nucleic acid constructs, hematopoietic stem cell identifier animals, and methods of using thereof for isolating hematopoietic stem cell populations. Also provided are methods of using the identifier animals and cells isolated from them to screen for agents that affect the growth, proliferation, potency, expansion, or maintenance of the stem cells. Such agents can be used for promoting growth of stem cells in vitro or in vivo, and also for inhibiting cancer cells that have been determined to resemble a stem cell.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 25, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick J. Rossi, Roi Gazit
  • COMPOSITIONS AND METHODS FOR REPROGRAMMING HEMATOPOIETIC STEM CELL LINEAGES
    Publication number: 20160032317
    Abstract: Provided herein are compositions, methods, and kits for hematopoietic stem cell induction or for reprogramming cells to the multipotent state of hematopoietic stem cells. In some embodiments, the compositions comprise at least one HSC inducing factor. Such compositions, methods and kits can be used for inducing hematopoietic stem cells in vitro, ex vivo, or in vivo, as described herein, and these induced hematopoietic stem cells can be used in regenerative medicine applications and therapies.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick Rossi, Jonah Riddell, Roi Gazit
  • HEMATOPOIETIC STEM CELL SPECIFIC REPORTER MOUSE AND USES THEREOF
    Publication number: 20150223436
    Abstract: Described herein are nucleic acid constructs, hematopoietic stem cell identifier animals, and methods of using thereof for isolating hematopoietic stem cell populations. Also provided are methods of using the identifier animals and cells isolated from them to screen for agents that affect the growth, proliferation, potency, expansion, or maintenance of the stem cells. Such agents can be used for promoting growth of stem cells in vitro or in vivo, and also for inhibiting cancer cells that have been determined to resemble a stem cell.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 13, 2015
    Inventors: Derrick J. Rossi, Roi Gazit