Patents by Inventor Roland A. Owens

Roland A. Owens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of using adeno-associated virus rep protein
    Patent number: 6821511
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: November 23, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert M. Kotin, Brian Safer, John A. Chiorini, Matthew D. Weitzman, Roland A. Owens, Stephen M. Wiener
  • Lipid vesicles containing adeno-associated virus Rep protein for transgene integration and gene therapy
    Publication number: 20020012997
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Application
    Filed: August 3, 2001
    Publication date: January 31, 2002
    Inventors: Robert M. Kotin, Brian Safer, John A. Chiorini, Matthew D. Weitzman, Roland A. Owens, Stephen M. Wiener
  • Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
    Patent number: 6342390
    Abstract: A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep protein (or a nucleic acid sequence encoding an adeno-associated virus rep protein) and a genetic construct including at least one DNA sequence encoding a protein or polypeptide or genetic transcript of interest and a promoter controlling the at least one DNA sequence. The genetic construct also includes a first adeno-associated virus ITR or protein or derivative thereof and a second adeno-associated virus ITR or a portion or derivative thereof. The first and second adeno-associated virus ITRs or portions or derivatives thereof flank the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest and the promoter controlling the at least one DNA sequence encoding the protein or polypeptide or genetic transcript of interest.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: January 29, 2002
    Assignee: The United States of America as represented by the Secretary of Health and Human Services
    Inventors: Stephen M. Wiener, John A. Chiorini, Brian Safer, Robert M. Kotin, Matthew D. Weitzman, Roland A. Owens