Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein Rx, Ry, Rz and Rzz are selected from: a) Rx and Ry are F and Rz and Rzz are H; b) Rx, Ry and Rzz are independently halogen and Rz is H; c) Rx Rz and Rzz are independently halogen and Ry is H; and d) Rx Ry and Rz are independently halogen and Rzz is H.

Abstract: An apparatus comprising a transmission unit comprising a light element that is configured to emit light in a predefined wavelength range; and a transmission optics that is configured to direct the emitted light to an object; a reception unit comprising a first reception element; a second reception element that is arranged spaced apart from the first reception element; and a reception optics that is configured to receive light remitted by the object and to direct it to the first reception element and the second reception element; and an evaluation unit that is configured to evaluate light received by the first reception element and to determine a distance of the object and to evaluate light received by the second reception element and to determine a color of the object.

Abstract: The present invention relates to an optoelectronic sensor system for detecting objects in a monitored zone having a light transmitter for transmitting light into the monitored zone along a transmitted light path, having a light receiver for receiving received light from the monitored zone that is remitted along a received light path in the direction of the light receiver from an object to be detected in the monitored zone or a reflector bounding the monitored zone, and having an objective arrangement arranged in front of the light transmitter and the light receiver. The transmitted light path and the received light path run spaced apart from one another at least in part sections facing the light transmitter and the light receiver respectively.

Abstract: The present invention relates to an optoelectronic sensor system for detecting objects in a monitored zone having a light transmitter for transmitting light into the monitored zone along a transmitted light path, having a light receiver for receiving received light from the monitored zone that is remitted along a received light path in the direction of the light receiver from an object to be detected in the monitored zone or a reflector bounding the monitored zone, and having an objective arrangement arranged in front of the light transmitter and the light receiver. The transmitted light path and the received light path run spaced apart from one another at least in part sections facing the light transmitter and the light receiver respectively.

Abstract: The invention relates to an optical sensor having a light transmitter for transmitting transmitted light into a detection zone, having a first and a second light receiver which are configured for receiving received light from the detection zone which is reflected in a reflective or diffuse manner and for generating received signals from the received light, and having an evaluation unit for generating a detection signal from the received signals. The light receivers are arranged such that each light receiver receives a portion of the received light. Each light receiver has an effective reception surface, with the effective reception surface of the second light receiver being smaller than the effective reception surface of the first light receiver such that the ratio between the received signal generated by the first light receiver and the received signal generated by the second light receiver depends on the sensing distance of the detected object.

Abstract: The invention relates to an optical sensor having a light transmitter for transmitting transmitted light into a detection zone, having a first and a second light receiver which are configured for receiving received light from the detection zone which is reflected in a reflective or diffuse manner and for generating received signals from the received light, and having an evaluation unit for generating a detection signal from the received signals. The light receivers are arranged such that each light receiver receives a portion of the received light. Each light receiver has an effective reception surface, with the effective reception surface of the second light receiver being smaller than the effective reception surface of the first light receiver such that the ratio between the received signal generated by the first light receiver and the received signal generated by the second light receiver depends on the sensing distance of the detected object.