Patents by Inventor Roland D. Green
Roland D. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8129196Abstract: The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.Type: GrantFiled: November 12, 2008Date of Patent: March 6, 2012Assignee: Roche Nimblegen, Inc.Inventors: Roland D Green, Mark McCormick, Gary Barrett
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Patent number: 7745118Abstract: The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.Type: GrantFiled: April 8, 2005Date of Patent: June 29, 2010Assignee: Roche Nimblegen, Inc.Inventors: Roland D Green, Steve Smith, Thomas Albert, Emile F. Nuwaysir
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Publication number: 20090069197Abstract: The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.Type: ApplicationFiled: November 12, 2008Publication date: March 12, 2009Applicant: Roche NibleGen, Inc.Inventors: Roland D. Green, Mark McCormick, Gary Barrett
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Patent number: 7482170Abstract: The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.Type: GrantFiled: September 30, 2003Date of Patent: January 27, 2009Assignee: Roche Nimblegen, Inc.Inventors: Roland D. Green, Mark McCormick, Gary Barrett
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Publication number: 20040101949Abstract: The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handling robot or an assembly robot or machine.Type: ApplicationFiled: September 30, 2003Publication date: May 27, 2004Inventors: Roland D. Green, Mark McCormick, Gary Barrett
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Publication number: 20030118485Abstract: A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized.Type: ApplicationFiled: August 23, 2002Publication date: June 26, 2003Applicant: Wisconsin Alumni Research FoundationInventors: Sangeet Singh-Gasson, Yongjian Yue, Roland D. Green
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Patent number: 6444175Abstract: A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized.Type: GrantFiled: November 9, 2001Date of Patent: September 3, 2002Assignee: Wisconsin Alumni Research FoundationInventors: Sangeet Singh-Gasson, Yongjian Yue, Roland D. Green
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Publication number: 20020061262Abstract: A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized.Type: ApplicationFiled: November 9, 2001Publication date: May 23, 2002Applicant: Wisconsin Alumni Research FoundationInventors: Sangeet Singh-Gasson, Yongjian Yue, Roland D. Green
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Patent number: 6315958Abstract: A flow cell which can be used in the synthesis of DNA probes on an active surface of the substrate includes a base having a central window opening and a registration surface against which the substrate may be mounted. A gasket having a central opening defining an active area is mounted on the active surface of the substrate and has inlet and output extension openings which extend away from the central opening. A press block is engaged against the gasket to fully enclose an active volume between the press block, the peripheral walls of the central opening in the gasket, and the active surface of the substrate. A press is mounted to the base to selectively press the press block against the gasket and hold it in position. Channels in the press block extend to the extension openings in the gasket to allow flow of reagent into and out of the active volume, which is confined to the thickness of the gasket and can thus be minimized.Type: GrantFiled: November 10, 1999Date of Patent: November 13, 2001Assignee: Wisconsin Alumni Research FoundationInventors: Sangeet Singh-Gasson, Yongjian Yue, Roland D. Green