Patents by Inventor Roland Dunbrack

Roland Dunbrack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289823
    Abstract: The present disclosure provides polypeptides of netrin G1 (NetG1) and its cell surface receptor netrin G1 ligand (NGL1), and antibodies thereto, and methods of making such antibodies. The disclosure also provides uses of these NetG1 and NGL1 polypeptides, and antibodies thereto, in methods of treating cancers and diseases, including chronic fibrosis, inflammation, and inflammation-related diseases.
    Type: Application
    Filed: April 24, 2020
    Publication date: September 15, 2022
    Inventors: Edna Cukierman, Ralph Francescone, Debora Vendramini-Costa, Kristopher Raghavan, Janusz Franco-Barraza, Roland Dunbrack
  • Publication number: 20170183374
    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
    Type: Application
    Filed: December 27, 2016
    Publication date: June 29, 2017
    Inventors: Paul Michael Watt, Roland Dunbrack
  • Patent number: 9611321
    Abstract: Methods for generating hybrid antibodies are provided.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: April 4, 2017
    Assignee: Fox Chase Cancer Center
    Inventors: Gregory P. Adams, Heidi H. Simmons, Matthew K. Robinson, Roland Dunbrack, Andreas Lehmann
  • Patent number: 9567373
    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: February 14, 2017
    Assignee: Phylogica Limited
    Inventors: Paul Michael Watt, Roland Dunbrack
  • Publication number: 20140234213
    Abstract: Methods for generating hybrid antibodies are provided.
    Type: Application
    Filed: May 29, 2012
    Publication date: August 21, 2014
    Inventors: Gregory P. Adams, Heidi H. Simmons, Matthew K. Robinson, Roland Dunbrack, Andreas Lehmann
  • Publication number: 20140128268
    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
    Type: Application
    Filed: September 26, 2013
    Publication date: May 8, 2014
    Applicant: Phylogica Limited
    Inventors: Paul Michael Watt, Roland Dunbrack
  • Patent number: 8575070
    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: November 5, 2013
    Assignee: Phylogica Limited
    Inventors: Paul Michael Watt, Roland Dunbrack
  • Publication number: 20130108547
    Abstract: Compositions and methods useful for the diagnosis and treatment of cancer are provided.
    Type: Application
    Filed: May 12, 2011
    Publication date: May 2, 2013
    Applicant: FOX CHASE CANCER CENTER
    Inventors: Roland Dunbrack, Matthew K. Robinson, Andreas Lehmann, Gregory P. Adams
  • Publication number: 20120108791
    Abstract: Rotamer libraries and methods of use thereof are provided.
    Type: Application
    Filed: April 20, 2010
    Publication date: May 3, 2012
    Inventors: Roland Dunbrack, Maxim Shapovalov
  • Publication number: 20080081768
    Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
    Type: Application
    Filed: February 7, 2007
    Publication date: April 3, 2008
    Inventors: Paul Watt, Roland Dunbrack